Do you have any symptoms at present? The nerve innervating (supplying) the thumb, the index finger and the middle fingers is the median nerve. This can get compressed in the wrist, leading to numbness of these areas leading to a condition called Carpal Tunnel Syndrome.
This condition is common in those who use the keyboard, mouse etc a lot—like in computers or in typing jobs. The carpal tunnel (at your wrist through which the median nerve passes) changes its size depending on the position of the wrist. It’s widest when wrist and hand are straight in line. When the hand is bent up or down, the tunnel becomes slightly smaller. This then presses on the nerve which then causes a pain right up to the arm. Often proper working style, working without bending wrist, using smooth movements to operate the mouse and keypad, and relaxing the joints of finger, wrist and arm in between helps. A wrist support or arm support too helps and you have computer chairs with support for your spine and arm
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