Well my friends I am back again concerning poor little Hissie. She had been doing wonderful since her last vet stay several weeks ago. Eating good, socializing a lot, putting on weight, having bowel movements, etc. We still have her on the Wellness catfood, that she still is really liking. Giving her the two meds as we should daily. Then, in the middle of the night last night, she starts throwing up and straining to have a bowel movement. I saw it all for myself, as she was lying at my feet, while I was on the computer. Threw up several times under the computer desk. Then, went to our bedroom and threw up several more times. I saw her twice last night, straining so hard to have a bowel movement. And she was meowing while attempting to poop. She has never done that before, even with all the trouble we have had with her, the past few months. I clean out her litterbox daily. She has been having bowel movements everyday. I just cleaned out her litterbox several hours, before she got sick last night. She had had bowel movements then in her box, also. Last night though, we gave Hiss her meds. There was some slight liquid poop, when my husband picked her up, to wrap her in the towel, to give her the meds. Then, there was several small spots on the bedroom carpet as well. I have read that with constipation, there can be some seepage, that is liquid like. I am noticing something though and I don't mean to be gross. But, when I clean her litterbox everyday, her poops are 5 or 6 small balls. And they are very dark colored. I would call the color black. I know meds can effect color of bowel movements. But, Hissie's bowel movements have been like this even before the meds. She has never bled from the rectum. But, I know in humans, black stools are not a good sign...usually means there is blood in the stools. When my husband picked her up tonight so we could give Hissie the meds, her rectum was protruding out some. I am assuming was when she was straining so hard. We have done everything that the vet has told us to do. Those of you that know me by now, know that I am very upset and worried over my Hissie girl...again. Someone posted to me before, that when their cat was so ill, that it took a stressful toll on the pet owner as well. PrettyKitty I think it might have been you. Well, I am to that point as well now. And my poor husband is, too. Hissie is in her kitty bed now and has been for about 3 hrs. I am still up. If Hiss were feeling good right now, she would be out her with me, while I am on the computer. So, I know she is not feeling good. I been up all night. Just cannot sleep because I am worrying over Hiss. At this point, my plan is to put the meds aside, buy the husk today and order the enzyme online today. Like I said, I did it the way the vet wanted. Now I am going to try other alternatives, that I know have worked for other kitties on this forum. Thank you my friends for listening to me....again.