When a cat stops using their litter box it either means they are unhappy with something or emotionally stress or their is a physical problem. You're best bet would be to get kitty checked out at the vet
heres an article with some suggestions, you can read through it and see if something there helps track down the issue for you, if not come back and we'll try to help...don't give up there is always a reason:)
http://healthypets.mercola.com/sites/healthypets/archive/2011/06/16/tracking-down-the-cause-of-your-cats-bad-bathroom-habits.aspx