Where to from here with celiac

I have posted my Enterolabs results.  Does anyone know where I can find more info about what tests I should have to really determine how much damage Celiac has done to me at this point.

I am 57 and have been sick for 27 years with mysterious illnesses with no answers, despite having good health insurance.  Quite frankly, these results have answer many questions in the family.  My mother woke up at the age of 59 with complete kidney failure from some in diagnosed autoimmune disorder after years of mysterious illnesses and fatigue with no answers.  After 7 painful years on dialysis she died.  We all need to spread the word..undiagnosed Celiac can KILL you.


A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value
Fecal Antigliadin IgA    198   (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA    88 Units   (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score    750 Units   (Normal Range <300 Units)

Fecal anti-casein (cow’s milk) IgA antibody    61 Units   (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1    0201  

HLA-DQB1 Molecular analysis, Allele 2    0604  

Serologic equivalent: HLA-DQ   2,1  (Subtype 2,6)

Interpretation of Fecal Antigliadin IgA:  Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

Interpretation of Fecal Antitissue Transglutaminase IgA:  You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

Interpretation of Quantitative Microscopic Fecal Fat Score:   A fecal fat score greater than or equal to 300 Units indicates there is an increased amount of dietary fat in the stool which usually is due to gluten-induced small intestinal malabsorption/damage when associated with gluten sensitivity. Values between 300-600 Units are mild elevations, 600-1000 Units moderate elevations, and values greater than 1000 Units are severe elevations. Any elevated fecal fat value should be rechecked in one year after treatment to ensure that it does not persist because chronic fat malabsorption is associated with osteoporosis among other nutritional deficiency syndromes.

Interpretation of Fecal anti-casein (cow’s milk) IgA antibody:  Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing:  HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

[CaseyMae]

Well, the gold standard of diagnosing Celiac is through blood tests and a biopsy done by endosopy.  The blood work will only come back positive if you are stil eating gluten.  My suggestion is to find a GI specialist and have the Celiac panel (blood tests) done and then schedule an endoscopy asap.  That way, the doctor can look with a microscope into your intestines and be able to tell just how much damage you have.  Have you ever had an endoscopy before?

[thecanary]

Never had an endoscopy, but blood work was negative.  I will do that.