I NEED INFORMATION ABOUT SOME MEDICINE

My friend (37 years old) was diagnosted with OVCA stage 4 on jun/2007. She had CA125= 9600.
Till now she got carbo + taksol, three cycle, than operation, than four cycle more, alergic (allergic) on taksol, ( CA125 dropped on 150), than celix, not working,(CA125=7600), than carbo + gemzer, first alergic (allergic) on carbo, than on gemzer, than cisplatin + taxol, alergic (allergic) on cisplatin,( CA125= 1100) taxol not working, now she has alceran, we think it is not working (CA125=7000). I read about CYTOXAN (or CYCLOPHOSPHAMIDE), about ABRAXANE and about PHENOXODIOL, that they are also used for OVCA. Does anybody knew them, used them, are they approved for OVCA and available, can I get them in Europe. Thank you for all information!!!!
WITH HOPE!  Erika

[Kamal S Saini, MD, MRCP (UK), DM]

Hi Erika,
I am sorry to hear about your friend with advanced ovarian cancer.
She has already been exposed to most frontline drugs used in ovarian cancer - carboplatin, cisplatin, paclitaxel (Taxol), liposomal doxorubicin (Caelyx), gemcitabine (Gemzar), and melphalan (Alkaran).

Other potentially active agents include bevacizumab (Avastin),  docetaxel (Taxotere), oral etoposide, weekly paclitaxel (nab paclitaxel or Abraxane), pemetrexed, and topotecan. Less active agents in this setting include cyclophosphamide, capecitabine (Xeloda), irinotecan (Campto), ifosphamide etc.

Maybe she should have a discussion with her treating oncologist about intraperitoneal chemotherapy or preferably enrolling into a clinical trial.

Best Regards, and all good luck to your friend!

[tecla]

A related discussion, chemotherapy for ovarium cancer was started.