My uncle aged 60 was diagnosed with Lymphoma --> Non Hodgkins --> B-Cells.
He was to be provided with R-CHOP chemotherapy, but before starting this therapy,
a MUGA test for heart was conducted where his LVEF was found to be 37%.
Based on this, instead of Adriomycin(DOXIRUBIN), it is planned to administer Liposomal Adriamycin (Trade name - LIPODOX).
I saw in the following URL : http://www.biolik.com.ua/files/en/desc/lipodox.htm
a contraindication as follows:
leukopenia, trombocytopenia, an anemia, miocarditis, an acute heart attack of a myocardium (the expressed infringements of an intimate rhythm), an acute hepatites, a tuberculosis, a ulcer of a stomach, bilirubinemia, pregnancy, heavy infringements of function of a liver and kidneys..
So, based on his heart condition would it be safe to administer LIPODOX? Expert comments solicited.
Incidentally he is diagnosed as stage 4.
Adriamycin (doxorubicin) is a chemotherapy drug used for the treatment of lymphoma. This drug is cardiotoxic i.e it is toxic to the heart and the cardiotoxicity depends on the total cumulative dose administered.
Liposomal doxorubicin contains doxorubicin (Adriamycin) 'wrapped up' in a fatty covering called a liposome. This allows the doxorubicin to stay in the blood longer, so that more of the drug reaches the cancer cells. Doxorubicin encapsulated in liposomes can extravasate into tumours with abnormal "leaky" blood vessels, but may not penetrate normal tissues. Thus it has fewer side effects on healthy cells than regular doxorubicin.
The likelihood of cardiac toxicity is comparatively less with liposomal doxorubicin, but cardiac function needs to be monitored during and after completion of treatment.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.