My uncle aged 60 was diagnosed with Lymphoma --> Non Hodgkins --> B-Cells.
He was to be provided with R-CHOP chemotherapy, but before starting this therapy,
a MUGA test for heart was conducted where his LVEF was found to be 37%.
Based on this, instead of Adriomycin(DOXIRUBIN), it is planned to administer Liposomal Adriamycin (Trade name - LIPODOX).
I saw in the following URL : http://www.biolik.com.ua/files/en/desc/lipodox.htm
a contraindication as follows:
leukopenia, trombocytopenia, an anemia, miocarditis, an acute heart attack of a myocardium (the expressed infringements of an intimate rhythm), an acute hepatites, a tuberculosis, a ulcer of a stomach, bilirubinemia, pregnancy, heavy infringements of function of a liver and kidneys..
So, based on his heart condition would it be safe to administer LIPODOX? Expert comments solicited.
Incidentally he is diagnosed as stage 4.
Adriamycin (doxorubicin) is a chemotherapy drug used for the treatment of lymphoma. This drug is cardiotoxic i.e it is toxic to the heart and the cardiotoxicity depends on the total cumulative dose administered.
Liposomal doxorubicin contains doxorubicin (Adriamycin) 'wrapped up' in a fatty covering called a liposome. This allows the doxorubicin to stay in the blood longer, so that more of the drug reaches the cancer cells. Doxorubicin encapsulated in liposomes can extravasate into tumours with abnormal "leaky" blood vessels, but may not penetrate normal tissues. Thus it has fewer side effects on healthy cells than regular doxorubicin.
The likelihood of cardiac toxicity is comparatively less with liposomal doxorubicin, but cardiac function needs to be monitored during and after completion of treatment.
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