I am stage 1, tumor size 1.3 cm, no node involvement, had surgery and mammosite radiation, and now looking at chemo. (Originally diagnosed in March 2009, had surgery and mammosite in April 2009. I am ER positive, PR neg and HER neg) Had an oncotype score of 41, which I understand is pretty high. My oncologist originally recommended AC every 3 weeks for 4 cycles, and Taxol for 12 weeks on a weekly basis; I objected to the 12 weeks of Taxol, and now he recommends TAC treatment for 6 cycles, mainly, I understand, because of the high Oncotype score, which he feels puts me at high risk even though I am node negative. I am really unsure if this is overkill--should I seek a 2nd opinion? I am concerned about toxicity, and of course, quality of life issues. thanks for your input.
As per current treatment guidelines, chemotherapy is recommended for stage 1 breast cancer with tumor size more than 1 cm or an HER-2 positive tumor with tumor size > 0.5 cm. A high Oncotype Dx score is associated with higher chances of tumor recurrence. Therefore chemotherapy is indicated in your case. The regimen your oncologist has recommended is consistent with current treatment guidelines. Most of the toxicity associated with chemotherapy is temporary and there are various drugs available to reduce the side effects.
All the best, and God Bless!
Do you think there is any significant difference in the original recommendation (AC for 4 cycles, followed by a Taxol drug for 12 weeks on a weekly basis) vs. TAC for 6 cycles? I am obviously much more comfortable with the TAC for 6 cycles from an emotional and psychological standpoint, but still want to do the right thing. thanks so much for your earlier response--it was very helpful.
TAC for 6 cycles is a perfectly valid regimen to choose.
There is no good data to suggest that 4xAC-->12 weekly Paclitaxel is better than 6xTAC, although the adverse effect profile may be different for the two regimens.
You may like to discuss with your oncologist the option of TAC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.