Medication Changes

Posted By Suzanne on June 01, 1999 at 11:11:27
My son Christopher was diagnosed with Infantile Spasms at the age of 19 months.  He is now 28 months.  He was initially on ACTH inject able, then prednisone and for the past four months he has been on Vigabatrin (Sabril) and at first it has helped; he had gone as long as three weeks without a seizure.  Then they became more frequent and his doctor increased his dose of Vigabatrin.  This seemed to make the seizures more frequent.  The dr. has since decreased it back to his original dose and he is having seizures daily.  He is talking about switching him to Depakote.  What I have read about this drug I do not like at all.  The drug he is on now has minimal side effects, I realize if it's not controlling the seizures it makes no difference.  But I would hate to have the seizures stop and have a different child on our hands.  Just as an aside; he was born healthy, my husband and I are in great health and there is no history of any seizure disorders in either of our families.  This did not develop in our son until very late & his MRI shows no structural abnormalities, physically he is fine, he does have learning disability issues, nothing dramatic.  We are wondering are there other drugs to suggest to our neurologist? Is depakote safe to use on a child this young?  For how long would he have to take this drug and if it were to be indefinitely would this increase the chances for liver damage?   How often should his liver be check?  Can a tolerance be built up to these drugs?










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