XXX chromosome disorder

[Raine9]

My friend gave birth to her second daughter a few days ago.  She had an amnio and the test revealed that the baby has XXX chromosome.  Her and her husband agonized on what to do but eventually they decided that the right thing to do was to have the baby.  The docs told them that the baby will probably be only a grade behind or she can possibly be a genius.  Just wondering if anybody else has had this experience and if they can share it.  Thanks!

[tomel]

Do you mean Fragile X?

[anxiousmomtobe?]

Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.

However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.

Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.
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Resources
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: [phone]
Fax: [phone]
Tel: [phone]
Email: ***@****
Internet: http://www.marchofdimes.com

National Dissemination Center for Children with Disabilities
P.O. Box 1492
Washington, D.C. 20013
USA
Tel: [phone]
Fax: [phone]
Tel: [phone]
TDD: 8006950285
Email: ***@****
Internet: http://www.nichcy.org

National Center for Learning Disabilities
381 Park Avenue South
#1401
New York, NY 10016
Tel: [phone]
Fax: [phone]
Tel: [phone]
Email: ***@****
Internet: http://www.ld.org

Learning Disabilities Association of America
4156 Library Road
Pittsburgh, PA 15234-1349
Tel: [phone]
Fax: [phone]
Tel: [phone]
Email: ***@****
Internet: http://www.ldaamerica.org

International Dyslexia Association
Chester Building
Suite 382
8600 LaSalle Road
Baltimore, MD 21286-2044
USA
Tel: [phone]
Fax: [phone]
Tel: [phone]
Email: ***@****
Internet: http://www.interdys.org

UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Caterham
Surrey, Intl CR3 5GN
United Kingdom
Tel: [phone]
Fax: [phone]
Email: ***@****
Internet: http://www.rarechromo.org

KS&A
11 Keats Court
Coto de Caza, CA 92679
USA
Tel: [phone]
Fax: [phone]
Tel: [phone]
Email: ***@****
Internet: http://www.genetic.org



For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone [phone]; web site www.rarediseases.org or email ***@****


Last Updated:   5/8/2001
Copyright   1995, 1996, 1997, 1998, 2001 National Organization for Rare Disorders, Inc.

[Raine9]

To answer your question, tomel, I'm not sure what is Fragile X.  Basically, she was born with an extra X chromosome.  Girls are normally XX, she is XXX.

Thank you for taking the time research anxiousmomtobe.  I will make a note of all the info.

I read a little about it on the internet but I was looking to hear from people who have a child with this disorder.  Just wanna hear about your experiences and the ways you've coped with the situation.

[Christy H]

hi Raine Although I do not have a child with Fragile X (my child has Autism ) i am a special ed teacher and have a student who has fragile X. He is 16 and is able to read at a first grade level. he can talk fairly well and is able to care for personal hygiene rather well. i do believe you mentioned that your friend has a daughter and with all the research that i have done; Fragile X effects boys to a more severe degree than girls simply because the XYX (male fragile X) is much more sensitive to more problems ( behaviors and the like). Your firends daughter has an wonderful chance to function like other children. I will tell you that the best thing you can do for yuor friend is be POSITIVE and when and ifthere are problems and she's stressed out reminder her of all the things that her daughter  can do because she will and i say this from experince get down about how functional her daughter is. Please reminder that in life its the little things that count and for me athough I do wish that my daughter did not have Autism I will say that my princess is the light of my life and each day she is a consistant reminder that she is happy and I wish that I could be happy like that. and i strive to be that happy. Good Luck to you and your friend,
Christy

[Raine9]

Thanks for the kind words. We will be very supportive of her and treat her daughter like she was our own.  She is God's creation.

[mogwai]

Hello, my name is Brandon, and I have a question for you, i had a sister that passed away at birth, her spinal cord wasn't attached to her brain, if she had lived, she would have been mentally and phisically handicapped, do you know the reason for this abnormality? If you do, i would greatly appreciate it if you would tell me, thank you

[mogwai]

Hello, this i Brandon again, I know a girl at my high school by the name of Olivia Lawrence, she has Rett syndrome, I would like to know, would Rett syndrome be caused by having Triplo X chromosomes, because I would really like to know, if you could tell me the if this is caused by having Triplo X chromosomes, I would really appreciate it, thanks again

[StealYourFace]

Hey there.

I have the xxx chromosome actually.
I'm fertile, and as far as i know i'm as smart as the average person.

I do have touretts, ADHD, and epilepsy, however i'm not sure that they're related.

but as far as i can tell i'm ok.