Dear Jim -
Thank you for your question about your sister-in-law and Depo-Provera. I'm afraid I am not qualified to answer your question completely. I can only tell you that there may be a slight increased risk for birth defects from the this drug - but the exact
natureNature-throid
Natures tears of that risk is unknown to me. I would recommend that your sister-in-law discuss at length any potential risks with her obstetrician.
With regard to your nephew - I think it very unlikely that what you describe is due to Depo-Provera.
Hope this helps. Good luck - Dr. EV.