1 gram of azithromycin is standard treatment for NSU. In your case 250 times 4 = 1000mg or a gram so yes you should take them all at once, at least 1 hour after eating and wait an hour to eat again. DO NOT CONSUME ALCOHOL FOR 24 HOURS after taking the tablets as this may cause them to fail. You may get a bit of diarrhoea, this is normal. Take care
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