Anyone had experience with Xolair for the treatment of chronic autoimmune urticaria?

[lenrosen]

My wife has been experiencing an outbreak of chronic hives for almost 2 years. It started after she broke some bones in her foot and in using crutches she got a pressure hive outbreak. We have tried controlling with H-1 antihistamines. They exacerbate her condition rather than control it. We recently tried hydroxychloroquine with adverse side affects. We have tried L-thyroxin treatment as well but the hives did not go into remission. These are delayed pressure hives and the outbreaks resolve and return with regularity depending on clothing, sitting on hard benches, wearing closely confining clothes and shoes, etc. We are now looking at a very expensive therapy, Xolair (Omalizumab) injections at $750 a pop. Before taking the plunge I am seeking personal experiences with this ************** for autoimmune urticaria so that we can make a more informed decision. I have read a number of studies and understand that immediate and delayed anaphylaxis has occurred on rare occasion in clinical trials. Any stories would be helpful to know.  

[rodrigolarosa]

Hello Fiz,

How is going your treatment? I have being had serious hives even taking antihistaminic and prednisone, and my doctor suggested to start xolair.
  

[Newnormal]

Have you had any relief yet? I just took my first shot and I haven't seen any improvement yet.

[Fizy45]

After fighting aganist the Urticaria for months (comeback after years)  I also received an Xolair injection.300 mg 44 days ago.

This injection worked on me and my non stopping urticaria dissappered a day later.Nothing comes out since then it just stopped.

You may think that I am happy or thank the xoalir right ? HELL NO !

This drug RUINED MY LIFE !

From the first day to 44th day I have had a terrible dizzynes,vertigo attacks and sleepy mood.Sometimes those problems got worse and I cant even drive a car.It just dont pass I feel terrible headaches,vertigo,lightheadness etc.My psycology is at the bottom and I am about to go insane.I pray god everday to get rid of these side effects.Urticaria is a very disturbing problem but this well I prefer to have urticaria for the rest of my life but I dont think that I can live any more with these vertigo attacks.

SO BEAWARE OF THESE SIDE EFFECTS FOLKS !

[pinkysati]

I have same reaction after my first injection. I never had hives like this before. My allergy was in control with H1 antihistamine. Doctor decided to give my xolair to keep my off my reactine but I ended up taking tons of other meds like Benadryl and prednisone. I am feeling like hell. I don't wanna take another injection.

[Islam_ossama]

I had the same,,,i took it a week ago with no result,,,evenworse had anaphylaxis

[ShannonSMR]

Hi JulesJo. I'm in the same boat. I just had my fourth Xolair injection and so far I haven't had much success, but I'm holding out hope. After reading about the clinical trials and everyone's success I just figured it would work for me immediately. After the first month it seemed okay, but I had to go on prednisone after the second and third shots. I had my fourth shot two days ago and like I said, I'm hopeful! I re-visited this message board today and was relieved to see a few people say it can take up to 5-6 months to work. To me that means there is still hope, although like you I was feeling pretty hopeless during months two and three. Hang in there!