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All Things Considered piece on Fosamax
Anyone hear the All Things Considered piece on how Fosamax became a bestseller for bone density? A great story, and a cautionary tale of our current pharmaceutical industry and their voracious hunger to sell meds.
What if you eat brassica and soy. Prostate cancer as I understand it is caused by too much testosterone, because it metabolizes partly into dehydroxytestosterone (or something like that), which causes both prostate problems and breast problems. (The same thing is blamed for baldness). And of course prostate problems will correlate with low testosterone by the time they manifest, since they mostly affect older men who naturally have declining levels of testosterone no matter what they eat. Not that you're wrong, just suggesting an alternative view. Again, there is no evidence of these problems in the places in Asia where the most soy is eaten, where the majority of the world's population live. I think the answer lies elsewhere, in the toxins replete in our society. This will bear out if the Chinese start getting lots of our diseases now that they've industrialized, but then again it hasn't happened in Taiwan, Japan, Hong Kong, Singapore, Thailand, or Malaysia, which industrialized long ago.
Just read an article By DR.W.The ratios you need to balance for ultimate prostate protection
Men using BHRT bio-identical hormone replacement. Research indicates that low testosterone increase a mans risk of prostate cancer. As natural MD have been pointing out
for decades, prostate cancer increases with declining testosterone levels and estrogens
may increase by up to 40% in mens bodies during declining testosterone. So suspicion is increasing that estrogens may be related to prostate cancer. One specific area of estrogen
and low 2/16 ratios in men. increasing consumption of Brassica vegetables and flaxseed
can also increase the male 2/16 ratio ( though it's likely best for men to avoid regular soy consumption because of its plant estrogen content. research in Seattle found that men who ate Brassica vegetables 4 times a week have 40% less risk for prostate cancer.
Men using BHRT bio-identical hormone replacement. Research indicates that low testosterone increase a mans risk of prostate cancer. As natural MD have been pointing out
for decades, prostate cancer increases with declining testosterone levels and estrogens
may increase by up to 40% in mens bodies during declining testosterone. So suspicion is increasing that estrogens may be related to prostate cancer. One specific area of estrogen
and low 2/16 ratios in men. increasing consumption of Brassica vegetables and flaxseed
can also increase the male 2/16 ratio ( though it's likely best for men to avoid regular soy consumption because of its plant estrogen content. research in Seattle found that men who ate Brassica vegetables 4 times a week have 40% less risk for prostate cancer.
Don't get respirate started on soy. I'm a he, not a her, by the by. Not that it matters.
Oh, forgot to rant about the lovely frustration and subjective line between penia and perosis.. hmmm Makes you wonder what our medical providers are really up to!
Lol...let her get started on Soy! hehe...i can't eat soy anyway because allergy rofl.
I listened to the APR piece on Fosamax. I was completely taken aback! I have never really been concerned about my bones (although I should be) because i have had soooo many breaks during my lifetime, even a back break I didn't know about that fused itself (lucky i guess). Just always figured I would be one of those ppl who end up with Osteoperosis...
I am going to start fighting back... adding Strontium to my supplements.
I listened to the APR piece on Fosamax. I was completely taken aback! I have never really been concerned about my bones (although I should be) because i have had soooo many breaks during my lifetime, even a back break I didn't know about that fused itself (lucky i guess). Just always figured I would be one of those ppl who end up with Osteoperosis...
I am going to start fighting back... adding Strontium to my supplements.
don't get paxiled started on soy.lol
When I was in La Leche League, we were told that humans are the only species that drink another species milk. I know there are some examples of a mother animal adopting another species but all in all, it's true.
The dairy industry, like the pharmaceutical industry, depend on sales and profits to survive and we are in a capitalistic society. Think of Archer Daniel Midland Corporation, or whatever it's called pushing soy and corn on everyone.
We are really victims of our economy.
The dairy industry, like the pharmaceutical industry, depend on sales and profits to survive and we are in a capitalistic society. Think of Archer Daniel Midland Corporation, or whatever it's called pushing soy and corn on everyone.
We are really victims of our economy.
Another thing that is profit driven and not science driven is the focus on calcium. Most Americans actually get too much calcium in their diets because they've been cajoled by the dairy industry to drink so much milk. Now, common sense says that with all the milk we were told to drink as kids, when our bones are formed, there shouldn't be any osteoporosis in this country, but we have an epidemic of it. So obviously milk isn't the solution. What many believe is it's a lack of magnesium, not calcium, that's the problem. Calcium and magnesium for an electrical balance on either side of bone tissue, and too much of one will leach out the other. Milk is very high in calcium, but has minimal magnesium.
The weird thing about the osteopenia thing is that it would appear that any woman, and it's mostly women they're talking about, who has kept herself thin will have thin arm and leg bones and have a higher chance of being diagnosed with osteopenia even though keeping themselves thin is healthy.
The weird thing about the osteopenia thing is that it would appear that any woman, and it's mostly women they're talking about, who has kept herself thin will have thin arm and leg bones and have a higher chance of being diagnosed with osteopenia even though keeping themselves thin is healthy.
Thank you for the information. I hope it will help and that, along with calcium, I won't lose any more bone. You are most kind to provide the documentation as well as how to obtain the supplement. I do not take any prescription medications currently except for antibiotics when needed (and don't like to do it!) and hope to keep it that way.
The Scientific Evidence for Strontium
The major human studies of strontium for osteoporosis involved a special form of the mineral called strontium ranelate.
In a 3-year, double-blind, placebo-controlled study of 5,091 women with osteoporosis, use of strontium at a dose of 2 grams daily significantly improved bone density and reduced incidence of all fractures as compared to placebo. Additionally, in a 3-year, double-blind, placebo-controlled study of 1,649 postmenopausal women with osteoporosis and a history of at least one vertebral fracture, use of strontium ranelate at a dose of 2 grams daily reduced the incidence of new vertebral fractures by 49% in the first year and 41% in the full 3-year period (as compared to placebo).6 Use of strontium also significantly increased measured bone density. No significant side effects were seen. Benefits were also seen in an earlier, smaller study.
A fourth study tested strontium ranelate for preventing osteoporosis in postmenopausal who have not yet developed it. In this 2-year, double-blind, placebo-controlled study, 160 women received either placebo or strontium ranelate at a dose of 125 mg, 500 mg, or 1 gram daily. The results showed greater gains in bone density the more strontium taken.
While some treatments for osteoporosis act to increase bone formation, and other decrease bone breakdown, some evidence suggests that strontium ranelate has a dual effect, providing both these benefits at once.
Other forms of strontium besides strontium ranelate, such as strontium chloride, have shown potential benefits in animal studies, but have not undergone significant testing in people.
Therapeutic Dosages
Based on current evidence strontium ranelate can be taken at a dose of 500 mg to 1 gram daily to prevent osteoporosis and at a higher dose of 2 grams daily to treat existing osteoporosis.
References
1. Reginster JY, Seeman E, DE Vernejoul MC, et al. Strontium ranelate reduces the risk of invertebral fractures in postmenopausal women with osteoporosis: Treatment of Perpheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005 Feb 22 [Epub ahead of print].
2. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporos Int. 2003. [Epub ahead of print].
3. Reginster JY, Deroisy R, Jupsin I. Strontium ranelate: a new paradigm in the treatment of osteoporosis. DrugsToday (Barc). 2003;39:89,101.
4. Reginster JY, Deroisy R, Dougados M, Jupsin I, Colette J, Roux C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. Osteoporos Int. 2002;13:925,31.
5. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis—a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab. 2002;87:2060,6.
6. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459,68.
7. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 1993;95:69S,74S.
8. Matsumoto A. Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone. ArchToxicol. 1988;62:240,1.
9. Marie PJ, Hott M. Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. Metabolism. 1986;35:547,51.
10. Marie PJ, Garba MT, Hott M, Miravet L. Effect of low doses of stable strontium on bone metabolism in rats. Miner Electrolyte Metab. 1985;11:5,13.
11. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 1993;95:69S,74S
12. Ferraro EF, Carr R, Zimmerman K. A comparison of the effects of strontium chloride and calcium chloride on alveolar bone. Calcif Tissue Int. 1983;35:258,60.
13. Ferraro EF, Glass RT. The effect of strontium chloride upon alveolar bone. J Periodontol. 1980;51:345,7.
14. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006;18 Suppl 1:S11-5.
15. O'donnell S, Cranney A, Wells G, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Database Syst Rev. 2006;:CD005326.
16. Halil M, Cankurtaran M, Yavuz BB, et al. Short-Term Hemostatic Safety ofStrontium Ranelate Treatment in Elderly Women with Osteoporosis. AnnPharmacother. 2007;41:41-5.
The major human studies of strontium for osteoporosis involved a special form of the mineral called strontium ranelate.
In a 3-year, double-blind, placebo-controlled study of 5,091 women with osteoporosis, use of strontium at a dose of 2 grams daily significantly improved bone density and reduced incidence of all fractures as compared to placebo. Additionally, in a 3-year, double-blind, placebo-controlled study of 1,649 postmenopausal women with osteoporosis and a history of at least one vertebral fracture, use of strontium ranelate at a dose of 2 grams daily reduced the incidence of new vertebral fractures by 49% in the first year and 41% in the full 3-year period (as compared to placebo).6 Use of strontium also significantly increased measured bone density. No significant side effects were seen. Benefits were also seen in an earlier, smaller study.
A fourth study tested strontium ranelate for preventing osteoporosis in postmenopausal who have not yet developed it. In this 2-year, double-blind, placebo-controlled study, 160 women received either placebo or strontium ranelate at a dose of 125 mg, 500 mg, or 1 gram daily. The results showed greater gains in bone density the more strontium taken.
While some treatments for osteoporosis act to increase bone formation, and other decrease bone breakdown, some evidence suggests that strontium ranelate has a dual effect, providing both these benefits at once.
Other forms of strontium besides strontium ranelate, such as strontium chloride, have shown potential benefits in animal studies, but have not undergone significant testing in people.
Therapeutic Dosages
Based on current evidence strontium ranelate can be taken at a dose of 500 mg to 1 gram daily to prevent osteoporosis and at a higher dose of 2 grams daily to treat existing osteoporosis.
References
1. Reginster JY, Seeman E, DE Vernejoul MC, et al. Strontium ranelate reduces the risk of invertebral fractures in postmenopausal women with osteoporosis: Treatment of Perpheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005 Feb 22 [Epub ahead of print].
2. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporos Int. 2003. [Epub ahead of print].
3. Reginster JY, Deroisy R, Jupsin I. Strontium ranelate: a new paradigm in the treatment of osteoporosis. DrugsToday (Barc). 2003;39:89,101.
4. Reginster JY, Deroisy R, Dougados M, Jupsin I, Colette J, Roux C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. Osteoporos Int. 2002;13:925,31.
5. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis—a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab. 2002;87:2060,6.
6. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459,68.
7. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 1993;95:69S,74S.
8. Matsumoto A. Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone. ArchToxicol. 1988;62:240,1.
9. Marie PJ, Hott M. Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. Metabolism. 1986;35:547,51.
10. Marie PJ, Garba MT, Hott M, Miravet L. Effect of low doses of stable strontium on bone metabolism in rats. Miner Electrolyte Metab. 1985;11:5,13.
11. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 1993;95:69S,74S
12. Ferraro EF, Carr R, Zimmerman K. A comparison of the effects of strontium chloride and calcium chloride on alveolar bone. Calcif Tissue Int. 1983;35:258,60.
13. Ferraro EF, Glass RT. The effect of strontium chloride upon alveolar bone. J Periodontol. 1980;51:345,7.
14. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006;18 Suppl 1:S11-5.
15. O'donnell S, Cranney A, Wells G, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Database Syst Rev. 2006;:CD005326.
16. Halil M, Cankurtaran M, Yavuz BB, et al. Short-Term Hemostatic Safety ofStrontium Ranelate Treatment in Elderly Women with Osteoporosis. AnnPharmacother. 2007;41:41-5.
Now for a bit of bad news: There’s not enough
strontium in our food to have a significant effect if you have osteoporosis already, so if you’re suffering from this condition, you should take strontium in supplement form. But if you don’t have osteoporosis, it’s a good idea to eat foods that contain more strontium to prevent it from occurring. The largest amounts of strontium are found in spices, seafood,
whole grains, root and leafy vegetables, and legumes. Until recently, the only source of supplemental strontium was Osteoprime, But now there are more sources for you to choose from. One of these is called Strontium Support and is made by the
company Advanced Orthomolecular Research (AOR) of Calgary. Each capsule of Strontium Support contains 227 milligrams strontium. Check your local
natural food or vitamin store to see if they carry this supplement. They can contact AOR at www.AOR.ca. (I have no connection, financial or otherwise, with AOR.)
I know you can buy it through the Tahoma Clinic Dispensary.
Add strontium to your supplement program. Take one 227-milligram
capsule three times a day. For those without
osteoporosis but higher risk (family history, immobility,etc.) one capsule daily is probably adequate for preventive purposes. And make sure you’re taking
even more calcium— 1,200-1,500 milligrams a day is a good general range—along with magnesium and other “backup” minerals and other nutrients.
strontium in our food to have a significant effect if you have osteoporosis already, so if you’re suffering from this condition, you should take strontium in supplement form. But if you don’t have osteoporosis, it’s a good idea to eat foods that contain more strontium to prevent it from occurring. The largest amounts of strontium are found in spices, seafood,
whole grains, root and leafy vegetables, and legumes. Until recently, the only source of supplemental strontium was Osteoprime, But now there are more sources for you to choose from. One of these is called Strontium Support and is made by the
company Advanced Orthomolecular Research (AOR) of Calgary. Each capsule of Strontium Support contains 227 milligrams strontium. Check your local
natural food or vitamin store to see if they carry this supplement. They can contact AOR at www.AOR.ca. (I have no connection, financial or otherwise, with AOR.)
I know you can buy it through the Tahoma Clinic Dispensary.
Add strontium to your supplement program. Take one 227-milligram
capsule three times a day. For those without
osteoporosis but higher risk (family history, immobility,etc.) one capsule daily is probably adequate for preventive purposes. And make sure you’re taking
even more calcium— 1,200-1,500 milligrams a day is a good general range—along with magnesium and other “backup” minerals and other nutrients.
After reading your post about Fosamax, I googled the NPR All Things Considered piece and read the script. I had the bone density test last summer which shows that I have osteopenia in every area of my body except my spine which showed low normal. It did show osteoporosis in one area of my neck. I am 59 and have been working out religiously since I was 25, eat well and take supplements including calcium.
My doctor immediately prescribed Fosamax. I read up on it and there was information about it causing deteriation of the jawbone. The doctor told me that it only occurs in people with compromised immune systems like someone with cancer on chemotherapy. However, a sixty year old acquaintance told me that within a year of starting Fosamax, she began losing her teeth. She said that her father was a dentist and that she had never had a problem with her teeth before.
So I told my doctor that I wanted to increase my intake of calcium and do a wait and see on the Fosamax. She told me that she's not worried about me for now but for what may happen to me in 20 years. The scenario sounded horrible--breaking a hip and dying--if I didn't start treatment now. But she conceded and we agreed that I would be screened again in a couple of years.
I am amazed at how the pharmaceutical companies drive diagnosis. For a long time, all we heard about was ADD and ADHD and children were increasingly placed on meds. Now, it seems, many people are diagnosed Bipolar. My husband was recently diagnosed Bipolar NOS-Not Otherwise Specified which means that he doesn't fit the criteria for I or II. He used to have "Adult Adjustment Disorder". And I have osteopenia.
My doctor immediately prescribed Fosamax. I read up on it and there was information about it causing deteriation of the jawbone. The doctor told me that it only occurs in people with compromised immune systems like someone with cancer on chemotherapy. However, a sixty year old acquaintance told me that within a year of starting Fosamax, she began losing her teeth. She said that her father was a dentist and that she had never had a problem with her teeth before.
So I told my doctor that I wanted to increase my intake of calcium and do a wait and see on the Fosamax. She told me that she's not worried about me for now but for what may happen to me in 20 years. The scenario sounded horrible--breaking a hip and dying--if I didn't start treatment now. But she conceded and we agreed that I would be screened again in a couple of years.
I am amazed at how the pharmaceutical companies drive diagnosis. For a long time, all we heard about was ADD and ADHD and children were increasingly placed on meds. Now, it seems, many people are diagnosed Bipolar. My husband was recently diagnosed Bipolar NOS-Not Otherwise Specified which means that he doesn't fit the criteria for I or II. He used to have "Adult Adjustment Disorder". And I have osteopenia.
It is very unreal. I think we are the only country in the world that allows the pharmaceutical industry and insurance industry to control our doctors and patient care.
I receive information on many pharmaceutical prod. from a relative in the ind.
it's unreal what goes on.
it's unreal what goes on.
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