Does 'Stool Transplantation' Work?
An Unconventional Therapeutic Approach for Clostridium difficile Infection
Albert B. Lowenfels, MD
DisclosuresApr 23, 2013
Is "stool transplantation" an effective therapeutic option for the management of recurrent Clostridium difficile infection? The investigators performed a small randomized trial in 42 patients with recurrent C difficile infection. A duodenal infusion of feces from 1 or more healthy donors was given to 16 patients, 13 patients received vancomycin only, and 13 received vancomycin with bowel lavage.
In the duodenal infusion group, 15 of 16 patients were considered cured after 2 treatments, compared with 4 of 13 patients receiving vancomycin (P < .001) and 3 of 13 patients receiving vancomycin with bowel lavage (P < .001). Initial diarrhea was the main adverse event in the infusion group, but it did not occur during follow-up.
The investigators used stool infusion -- an unconventional therapeutic approach for the management of recurrent C difficile infection, which is a troublesome clinical problem. The results were very effective, and this randomized trial greatly strengthens previously available anecdotal reports.
One of the findings in this report is that diversity of the microbiota in the bowel of patients with C difficile infection is significantly reduced compared with that in healthy persons, and that infusion of stool from a healthy donor restores stool bacterial diversity. On the basis of this report, patients with recurrent C difficile infection can now benefit from this inexpensive yet effective treatment.
I know it is probably too much of this subject. My only excuse it that it keeps popping up on the medical news sites and I am fascinated that such a simple approach is so effective. As I posted previously, it also appears to be effective in patients with ulcerative colitis and that is a wicked disease. And it also show potential in IBS patients too. While it is definitely an unsettling subject, for people suffering from gut disorders it seems like a very worthwhile approach to explore.
I guess tha at the least we'll all be prepared to offer some hope to any people we know who suffer from these maladies and that's probably a good thing. I wonder how many doctors discuss this approach with their patients.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.