any relation between warfarin long-term consumption and Motor neuron disease?

[ata68]

Two years ago, DVT was detected in my father(by ultrasonography). after that up to now he is under warfarin therapy. the potential reason for his dvt, i think was high amounts of plasma homocystein(50). after taking acid folic, his P.homocystein is back to normal. from the initial days of his warfarin therapy, he was complaining about weakness in his legs, the doctors said that it was related to dvt, but his legs grew weaker and weaker. also a new event, muscular fasciculations was seen in his arms. it is now some time that even his arms have got weaker. now we look forward to getting his MRI results. the doctor said that he was suspected for MND. I wonder whether it can be side-effect of warfarin.
I had studied in somewhere that vitamin K has an important role in CNS. so I'm suspected to warfarin.
Thanks for your care.

[Akbari]

salam!
I really don't know about warfarin and CNS, as so many people use it after stroke and you know this fact. but I haven't heard about its ffect on the nervous system. but about the MRI I really don't think that it could be helpful for diagnosis of neuromuscular defect. I think it is better to use EMG and NCV for diagnosis. a good neurologist and physiatrist can help you in my idea.
and may I know that how was your father activity and mobility in last two years? was he bed ridden for DVT?
pleas let me know about the result of MRI.

Good luck!  

[ata68]

well, for the first week after diagnosis, he was bedridden and got enoxaparine, after that up to now, he is under warfarin therapy.
I hope his weakness and fasciculation is due to warfarin, I hope.
tnx!

[Akbari]

why don't you check the list of warfarin side effects on the web?!

[ata68]

I have checked it so far.
the most relevant one to my idea, was its effect of increasing brain hemorrhage risk.
Now I'm all looking for any major role of Vit.K in CNS.