DEPRESSION/MENTAL HEALTH EXPERT FORUM
Burning sensation

Burning sensation

I have been taking 100mg's of Zoloft for 4 weeks now and it is having an antidepressant effect, however I am also getting paresthesia (burning, itching sensation on my skin) as a side effect. Had the same thing when I was recently on Paxil and Trazadone(the reason the switched me to Zoloft).  I never had this effect from an SSRI before (I was on Paxil for 1.5yrs a few years ago).
Is it likely that this side-effect will eventually go away?  If not, is there something else I can take to counteract it?
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Paresthesia is an unusual but possible side effect of the Serotonin Specific Reuptake Inhibitors (SSRIs), including Zoloft, Paxil, Prozac, Celexa, and Luvox. It is difficult to predict if the paresthesia will resolve or not. If medical or dermatological causes of the paresthesia have been excluded, your treating physician/psychiatrist may consider treating you with an anti-histaminic medication such as Benadryl, or switch you to a non-SSRI antidepressant such as Wellbutrin or Remeron.
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it is unlikely to be histamine mediated. Doubt that benadryl will do anything. can give it a try if you like.

Dysthesias are common on zoloft in the startup period. Benzos will usually help with this as will beta blockers.

The beta blockers blunt the effect, but usually do not stop it.

Klonopin is usually used for this type of side effect & is probably the best choice. It tends to abort the adrenergic surges that the dysthesia is accompanied by.
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