Can Effexor XR and Wellbutrin SR be taken concurrently?

[jmhtexas]

I have been taking 150mg of Effexor XR for about 5 months. Sometimes, especially on weekends, I get extremely lethargic.

I understand Wellbutrin doesn't pull you down as much; however, under most circumstances the Effexor controls depressive syptoms very well.

Can Effexor XR and Wellbutrin SR be taken concurrently? If so, what is the maximum recommended dosage for each drug?

Thanks,
jmhtexas

[lvsredsox]

I want to quit effexor, I take 225 mg and substitute with wellbutrin. I have a feeling this will be really hard since I have been of effexor for 15 years. any ideas how to lesson the withdrawals?

[jmhtexas]

Jeanette,
Thanks for your comments. You are taking a low dosage of Effexor. Are you tapering off or do you find that dosage is sufficient when combined with Wellbutrin? Blue skies!

[Roger Gould, M.D.]

Usually wellbutrin is adjunct to decrease sexual side effects from antideps.  
but, sure. can combo both.  would use short acting wellb (not SR).  max dose
depends on ability to tolerate and MD's level of comfort!  I've used W 200
mg/d with lower dose SSRI.  I don't use much effexor, so can't say much about that. You should consult your doctor.

[Jeanette]

Hello :)

I take both Effexor and wellbutrin.  I take 450mg of wellbutrin sr and 37.5mg (for now) of effexor.  I have been told that the recommended dossage should not exceed 450mg of wellbutrin sr due to the siezure increase.