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Medication Interactions??
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Medication Interactions??

I am a middle aged female who has both trigeminal neuralgia and migraine headaches.  I have been treated for 5 years by a neurologist for these conditions; current meds are: Trileptal(4xday@150mg dose); Elavil (150mg @ bedtime); Ultram, Lortab 10/500 or Celebrex up to 3xday for severe pain.  

I have been referred by my neurologist to a psychiatrist for depression (diagnosis: major depression)due to chronic pain, stress of living with this condition, family problems, on & on. My psychiatrist placed me on Zoloft 50 mg 1x day which I've been on for exactly 4 weeks.  I have developed extreme irritability, my pain threshold has seemed to diminished to where pain meds/preventatives aren't working like they once did.  Could this be due to the addition of Zoloft or the depression itself? Or meds interacting in a negative way?  I have an appointment for a med assessment with my neuro. 2 weeks from now..just curious of your opinion until then. I feel so helpless living in this physical/mental state, not to mention the chronic pain.
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Yes, Zoloft can cause the response you described. All of your other medications are processed through your liver through the same enzyme system, so they may be accumulating into higher effective blood levels. You should discuss this with your doctor.
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