I have been on Paxil for about 9 years now and have noticed a slow increase in my weight. I do drink 5 - 6 glasses of red wine per week, so I haven't been sure if the weight gain is from alcohol, or from Paxil. One thing I have directly related to Paxil is my increased hunger. I am always hungery and it is really irritating. I am very lucky that I have only gained 10-15 lbs and am still at a healthy weight for my 5'2 frame (124 lbs) but it ***** being hungry all the time and having extra weight! My doctor told me that weight gain is a side effect of Paxil so I am going to try Zoloft. I have an anxeity disorder that triggers OCD and Paxil has worked very very well and given me a great life since being on it. I figure I should try something different to see if it helps the weight gain and if Zoloft doesn't work, or help me to lose the weight then I will have to cut off the wine and go back on Paxil. Suffering from Anxiety *****, but I would take the weight gain over feeling freaky all the time! I will check back after a few months of being on Zoloft to report on the changes.