Wellbutrin with Zoloft

I'm an experienced user of Zoloft and recently went back on it 6 weeks ago after have a very stressful 2 month period in my life.  I'm taking 100 mg. It creates sexual side affects so I thought I'd try Wellbutrin 75mg 2xday.  Is this a pretty successful treatment of this symptom? I'm male, 44 yrs old, in good shape.  Used Zoloft for 12 yrs but hadn't been on it for the last 2 yrs. I'm just starting to date someone and have to get a handle on this problem.

[Abhijeet Deshmukh, MD]

Hello.

Combining Wellbutrin with Zoloft (and SSRIs) has documented benefits. The combination helps reduce the symptoms and reduce the sexual side effects cause by Zoloft. Reviews of multiple studies on this combination have yielded the same results. Here are a few links for you.

http://www.ncbi.nlm.nih.gov/pubmed/16165100

http://www.ncbi.nlm.nih.gov/pubmed/20067456

http://www.ncbi.nlm.nih.gov/pubmed/17009913

You can go ahead with the addition of Wellbutrin, with your treating doctor's prescription.

Best regards