affects of taking zoloft with a metabolizer

I am currently taking zoloft and I am trying to lose some weight I put on a few years ago.  Someone suggested I try a dietary supplement that increases thermogenesis.  My concern is whether it is safe to use with the zoloft.

[Roger Gould, M.D.]

According to standard medical information, there should be no problem, but you never know, so try to find a site that deals specifically with drug-drug interactions to make sure this won't be a problem.

[ontherecord]

If the thermogenic supplement contains ephedra -- and I am sure it does -- you're better off not mixing the two.  Chances are nothing untoward will happen, but increased serotonin levels have an excitatory effect, which may be enhanced by the Zoloft.  

Bottom line: in mild doses, thermogenic supplements will probably do no harm, but in higher doses, you may be taking a chance.  In any event, do it right way: with time and sweat.