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I've known people on prozac, that quit cold turkey and had no withdrawal symtoms. I didn't have such luck with paxil,effexor.
Does prozac not have the withdrawal symtoms, is it not as likely to cause these problems?
Paxil is shorter acting and going cold turkey is almost impossible, whereas prozac is longer lasting, so stopping the oral medication means that you still have a blood level for longer and that gradually diminishes.
I have stopped taking 40 mg of Prozac cold turkey and I had no side effects, and I have done that several times over the years. When I stopped taking Effexor, the side effects felt terrible. Even tapering it down I still felt the side effects although to a lesser degree.
Paxil is a clone of Prozac but with a shorter half-life. Prozac leaves the body more slowly than Paxil. Perhaps this site (social audit site) would help to explain it, its one of many sites but at a quick guess it will probably give you a lead to answering your question fairly quickly :)
For more information on any of these, further searching will need to be done (using the title of the researhers/authors above each summary as a start?). The summaries do give a fairly short but comprehensive list of the results.
Prozac is the easiest SSRI to withdraw from because it has such a long half-life that it slowly leaves your body. Effexor is the hardest since it has the shortest half-life and one who is trying to taper will go in and out of withdrawal due to this. Paxil is also very difficult to taper and withdraw from... Please see the Class Action Lawsuit against GlaxoSmithKline which address this lack of disclosure:
August 24, 2001
FOR IMMEDIATE RELEASE
Baum, Hedlund, Aristei, Guilford & Schiavo
12100 Wilshire Blvd., Ste. 950
Los Angeles, CA 90025
Contact: Robin McCall, Media Relations
Day: (800) 827-0087 or (310) 207-3233
Night: (818) 558-5964
Victims File Lawsuit over Severe Withdrawal Reactions from the
Antidepressant, Paxil - First Class Action of its Kind Against an
Los Angeles, August 24, 2001 - - 35 people who have suffered from severe
withdrawal reactions as a result of taking the antidepressant Paxil, filed a
class action complaint today in California Superior Court, LA County,
against Glaxo Smithkline Corporation (GSK), formerly known as SmithKline
Beecham. This group represents thousands of Paxil users who have allegedly
suffered from withdrawal reactions and dependency/withdrawal syndrome. They
come from all walks of life (e.g., Lt. Col in the U.S. Air Force; former
star athlete; web-designer; children; bank fraud investigator and many more)
and reside throughout the United States. Each has experienced similar
withdrawal reactions and problems such as:
Paxil was introduced into the U.S. market on December 29, 1992, and is a
well known antidepressant medication in the same class as Zoloft and Prozac
(selective serotonin reuptake inhibitors or "SSRI's"). Paxil is approved for
marketing in the United States for conditions such as depression, obsessive
compulsive disorder, panic disorder, and "social anxiety disorder."
Complaint Allegations: 1) The complaint alleges Paxil can cause some people
who take it to experience serious and unexpected withdrawal reactions.
Neither the patients nor the physicians expect these withdrawal reactions
because, according to the complaint, the manufacturer has deliberately
failed to warn of their potential occurrence. Both physician and patient
unwittingly commit to Paxil without knowing the drug's addictive traits.
None of the named plaintiffs were ever informed before starting Paxil that
it was addictive, induced dependency, or created withdrawal reactions when
dosage was reduced or terminated.
2) Paxil creates both physical and psychological dependency because GSK has
suppressed the information about the severe withdrawal reactions of its
drug, many patients and their physicians are fooled into thinking that the
withdrawal reactions are caused by another condition (such as relapse), thus
prompting further incorrect and unnecessary medical treatment, including
increased dosages of Paxil.
3) GSK has known for years the distinct characteristics of Paxil which make
it prone to cause withdrawal reactions when discontinued. While the medical
community has acknowledged the potential for all SSRI's to cause
dependency/withdrawal syndrome, Paxil is, by far, the worst. According to
World Health Organization ("WHO") data obtained by the plaintiff class
members, Paxil has the highest incidence rate of withdrawal adverse
experiences of any antidepressant drug in the world. "Even despite our
clients' extreme difficulties caused by this drug, some remain on Paxil
today because they are "hooked" and fear they cannot get off the drug," says
attorney Mary Schiavo.
The complaint charges include fraud and deceit, negligence, strict
liability, breach of warranty and implied warranty which can be seen on the
The lawsuit was filed by Karen Barth (in association with Mary Schiavo) of
Baum, Hedlund, Aristei, Guilford & Schiavo in Los Angeles and Donald Farber
of San Rafael, California.
The attorneys have stated, "The scariest part about this is that there are
people out there trying to get off this drug who are experiencing these
horrible withdrawal reactions. They think its because of something wrong
with them, when it's really the Paxil - - and then they take even more and
further exacerbate the problem!"
Fact Sheet is available on the web along with the complaint at
22.The "patient years" standard is a sham by anyone's common sense.It works like this.Assume 366 patients are selected at random to test Paxil.Three hundred and sixty five (365) patients take Paxil and suffer horribly the first day--immediately quitting the test.These patients are called, not surprisingly, "losers."The 366th patient, however, tolerates Paxil quite well, and even improves on the drug, staying in one or more trials for a full year.This patient is a "winner" by SKB standards.Like a champion race horse, this "winner" is entered in all the sweepstake trials for Paxil--and these trials are intentionally programmed to be long.Knowing they have a champion race horse, SKB racks up "points."By anyone's common sense standards, 365 failures out of 366 attempts would render the drug a dismal failure.But not so under "patient years."Under patient years, the one Paxil patient who tolerated the drug for one year counts the same as the 365 patients who couldn't tolerate the drug and dropped out the first day.The "score" in this example is "one patient year" for each side.Not surprisingly, the mathematicians who go along with this voodoo math are subordinate to the physicians and clinicians in the corporate chain of command, and the physicians at the top of the FDA chain of command.
23.In Paxil's clinical trials, SKB ultimately achieved positive results--as it were--because of emphasis on "subjective" testing data.Objective data is very scientific.Subjective data is less scientific.The latter requires more stringent controls to be applied scientifically.Subjective data is subject to the biases, opinions, and prejudices of the person(s) collecting the data.SKB
GSK - your corruption, duplicity and total lack of concern for human life is appalling. Worse than that of the Tobacco Company. Worse than that of illegal Drug Dealers. Worse than Alcohol manufacturers. BECAUSE YOU maintain that your "mission is improving the quality of human life", here - on your website:
between the financial adverts on your page.
You make it difficult, almost impossible, for honest experts to speak out against you. You use your money and dishonesty to corrupt wherever you can what were once decent human beings who took the Hippocratic Oath. You "fund" and "treat" (or should I say Freebie and Bribe?) once ethical people. You humiliate those who try to bring out the truth. SHAME ON YOU. What an awful reflection you give of our species. Greedy, power-seeking, profit-searching, self interested, calculating people who will go to any lengths, walk over vulnerable children and adults, showing a total contempt for the quality of, or existence of, life. And for what?
FOR MONEY. FOR POWER. FOR PERSONAL GAIN.
Here are just two of your innocent victims.
A little girl - died aged 12:
A little boy - died aged 11:
And there are, as you know, many many more.
How DARE you do this to human beings?
please see my post the other antidepressant thread. Thyroid is the most misdiagnosed (ignored) issue in our culture today. Many people have gotten off prozac etc when they get their thyroid supplimented. Check the other thread for websites and discussion groups. Good luck!
There's a lot of truth in what you say. I'd just add that some people who have been on SSRIs didn't have thyroid problems UNTIL they went on SSRIs. SSRI's affect so many areas of the body - not only the brain and nervous system. In case you haven't see the FDA list of Adverse Effects of Prozac (which is as you know an SSRI just as Celexa, Paxil, etc are) here it is (and thats an old list and reliant on the proportion of doctors who actually reported adverse effects):
"FDA Statistics (Gained through the Freedom Of Information Act)
FDA REPORTED PROZAC CASES; TOTAL 35,230 (1987:-1995)
ALL FDA COSTART REACTION TERMS IN DATA ALPHABETICAL TERM ORDER - 04/10/96 -
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