Yes they do. Amitriptyline as a 5-HT2A, 5-HT2C, 5-HT6, 5-HT7, α1-adrenergic, H1 antagonist and this cause sleepiness and therefore this is why you should take them 30 min before bed time.
I suggest you use nortriptyline instead because it is a second generation tricyclic and it is the active metabolite of amitriptyline. This will induce less side-effects while getting the same benefits but they also cause sleepiness and should be taken 30 min before bedtime too.
I've been taking Amitripylin for yrs and yrs. I was started on a low dosage for sleep and threw the years my dose has gone higher. The med can take as little as ten minutes to start to work while with others it can take up to 2 hrs before feeling tired. Thats how I am some times as long as 2 and a half hrs before I go out, yet I fight it. At first though I get a little hyper, great time to do the dishes. If it does not seem to work after four weeks tell your doctor, maybe the dosage is not strong enough for you, never ever raise the dosage without your doctor said it is alright to do so. Since I have been taking it for so long I am now taking 150mgs two hrs before I fall asleep, yet every one is different, one person can do one thing yet another can do something else. Oh one more thing , I don't know if you drink or not yet never ever drink while taking amitripylin..Hope I helped..Cassie
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