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well i dont have any real suggestions...but thought i would share, i was on serzone, lost 30 pounds, went off that, went on zoloft gained 50 pounds....so then went off that and went on prozacProzac Prozac weekly and lost 20 pounds, then somehow i have gained weight.....about 10 pounds using a muscle relaxer and i believe effexor was 5 pounds..somewhere in there...so it is a nightmare..u gain on one, lose on another.....and it makes you more depressed... I believe CYMPBALTA has a low instance of weight gain... i know someone who went on that and lost 5 pounds so far.