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My best friend is extremely depressed and i dont know what to do

My best friend that ive known for over 10 years has been really depressed these past few months and ive talked to her and with her and i dont know what to do, shes transgender (mtf) and gets called the wrong name and pronoun almost everywhere she goes, whether at school or when shes ordering food and the person behind the counter calls her sir, ive called her and messaged her on snapchat and half the time i do shes crying thinking about things shes done 5-10 years ago in the past, i dont know why but shes told me that she really misses the early 2000's, so much so i came to her house while she was crying to the ending credits of the spongebob movie and she kept telling me that she would do anything to go back to 2004 when life was simple, she loves cars and has an old camaro in her garage that she told me shes "restomodding" but i havent seen any progress done on that car in over 4 months, she always details her other cars but they look really dirty and to see her car dirty is a very rare thing, she hardly goes out like she used to, she wont talk to anybody that she dosent know, she refuses to get into relationships, she deleted her facebook and says that humans are evil and that earth is a ball of cancer, i dont know why shes acting like this! Shes usually full of joy and the happiest and most loving and kind person you'll ever meet, i just dont know what to do
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Avatar universal
Suggest she goes to the doctor and they will hook her up with a good therapist, theres only so much you can do so don't feel guilty when she's depressed. None of it is your fault and being the best friend in a situation like this can be stressful at times but keep in mind its up to her and you can help but only to a certain extent. Being transgendered is hard and you're most likely to develop depression when you're trans so make sure she knows she's not alone. Maybe she could join a support group for transgendered people that could help a lot. If you guys are in high school make sure she knows that high school is just one chapter in your life, when she graduates and moves somewhere other than your hometown, meets new people, finds her niche and moves on with her life she will be a lot happier. Again, try not to be stressed out this is not up to you to make her better its up to her. Theres only so much you can do. Hope this helped :)  
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Avatar universal
You can suggest to her she's changed and needs to see a therapist to sort this out, but because she is in control of what she does this won't necessarily be easy.  Don't abandon her, let her know you care, try to help the best you can, but in the end, she has to do it herself, but maybe with a nudge.
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