Depression Community
Treatment Resistant Depression?
About This Community:

This patient support community is for discussions relating to depression, counseling, sleep problems, and nutrition.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Treatment Resistant Depression?

I am a 16 year old girl and have recently attempted suicide. I was hospitalized and my psychiatrist is now figuring out which drug I should take next. I have OCD and depression and have been in therapy since I was 7. I have taken the following drugs over the course of the past 9 years (not in order):

Luvox
Zoloft
Cymbalta
Effexor
Wellbutrin
Anafranil
Prozac
Seroquel
Ritalin
Orap
Lithium
Topamax
Risperal

I can't understand why none of them have any effect on me.  Do you have any suggestions? Help!
Related Discussions
5 Comments Post a Comment
Blank
Avatar_f_tn
Did you have certain things happen in your life that started this depression?  Or was your life really good and this unexplained depression started?  At any point during the past 9 years, did you have any relief from depression?  
Blank
Avatar_n_tn
All the medications you listed all help increase either serotonin or dopamine (brain neurotransmitters which regulate mood) but there are other neurotransmitters which can cause depression if your brain does'nt have enough of them.
The two other main neurotransmitters are GABA and endorphins.
Have you ever taken valium or a benzo or one of the over the counter relaxants like valerian or kava kava? These help increase GABA.
There is also a natural supplement called D-Phenylalanine that helps increase endorphins.

Go to this webpage which has lists of the symptoms of deficiency for all the neurotransmitters and tell me which one matches up the most with how you feel:
http://www.nutritional-healing.com.au/content/articles-content.php?heading=Neurotransmitter%20Deficiency%20and%20Excess%20Symptoms
Blank
Avatar_f_tn
Nothing brought on the depression.  There has been no deaths, abuse or anything traumatizing.  When my OCD symptoms flare it seems that my depression symptoms reduce and visa versa.
Blank
Avatar_f_tn
I would say both serotonin deficiency and GABA deficiency fit me pretty well.  My stress levels are off the charts mostly because I am an extreme perfectionist when it comes to my schoolwork.
Blank
Avatar_n_tn
That's pretty interesting that you say your condition alternates between OCD and Depression, I think I may know why that is but it's only a theory.

Basically what antidepressants do is recycle the same serotonin in your brain so that it stays there longer, but it does'nt actually add any new serotonin into your brain. There are dietary supplements you can take which can actually add new serotonin into your brain (L-Tryptophan, 5-HTP), the way we get serotonin is actually through our diet but your diet could be lacking in it. There are also supplements to increase GABA, some of them being Valerian root, Kava and Picamilon (probably the best one but takes longer to work).

If there is hardly any serotonin in your brain to start with then antidepressants may not work as they only recycle the serotonin already in your brain.

GABA and serotonin work together and if the levels of one of them are decreased, then it will usually affect the both.

Have a look up about the supplements but you would need to be very careful taking 5-HTP or L-Tryptophan if you are already on an antidepressant right now. To start with I'd recommend you get Valerian which is easily available in most chemists or health food shops and let us know if it helps at all with the stress.
Blank
Post a Comment
To
Recent Activity
480448_tn?1397235344
Blank
nursegirl6572 commented on specialmom's status
2 hrs ago
8407277_tn?1397994497
Blank
Aashish_7 commented on evewisewoman's status
3 hrs ago
6827092_tn?1389388419
Blank
007Bunny commented on 007Bunny's status
3 hrs ago
MedHelp Health Answers
Blank
Mood Tracker
Track your mood over time
Start Tracking Now
Top Mood Disorders Answerers
1110049_tn?1384640486
Blank
4Maddie44
Dorset, United Kingdom
6726276_tn?1388332222
Blank
CRSeaside
Huntington Beach, CA
585414_tn?1288944902
Blank
ILADVOCATE
NY
480448_tn?1397235344
Blank
nursegirl6572
PA
574118_tn?1305138884
Blank
adel_ezz
cairo, Egypt
Avatar_f_tn
Blank
remar
st. louis, MO
Depression Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
How to Silence Your Inner Critic an...
Apr 16 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eaters: How to Silence Yo...
Mar 26 by Roger Gould, M.D.Blank
1344197_tn?1392822771
Blank
Vaginal vs. Laparoscopic Hysterecto...
Feb 19 by J. Kyle Mathews, MD, DVMBlank
Top Mood Disorders Answerers
1110049_tn?1384640486
Blank
4Maddie44
Dorset, United Kingdom
6726276_tn?1388332222
Blank
CRSeaside
Huntington Beach, CA
585414_tn?1288944902
Blank
ILADVOCATE
NY
480448_tn?1397235344
Blank
nursegirl6572
PA
574118_tn?1305138884
Blank
adel_ezz
cairo, Egypt
Avatar_f_tn
Blank
remar
st. louis, MO