How can I safely-effectively wean myself off of Seroquel especially and at a later date topomax. I have put on 25 lbs. over 10 years and the Seroquel knocks me out at night and I feel groggy the next morning. 200 mg at night. I've lowered it to 100 mg each night this past week. I hope to do this for one month and see how it goes. My husband and I both dispute the bi-polar diagnosis of 10 years ago; not out of denial (as we are both very educated) but because of the symptoms. I was going through a bad depressive time. Many people do. I was put on so much medication I was like a zombie. I was put on lithium and bloodwork was not done regularly and only because of my insistance, it got done and my kidneys were troubled. Off of that and I am now on the above. I went through 7 months of unknown hives/welts, swelling, breathing difficulties last year - saw every specialist imaginable and no allergies - thyroid under (which has been for years) - Hashimoto's and angio-edema. Was put on plaquenil which was horrible and then methotrexate (toxic) - I stopped all of it because I knew it was poison. After 2 months - everything disappeared and I have had nothing come back. I think the medication was causing problems. HELP!!!!! Thank you! Chickpea