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I believe we may have messaged in the addictionDrug abuse and dependence forum as well. I know when I took CymbaltaCymbalta my doctor said it could take anywhere from 4-6 weeks to take full effect. I began to notice a difference in only about a week. It is hard to be patient, if you are like me, for it to start working because often with depression we can't see that far ahead out of the dark cloud. I am glad your doc is treating what may the underlying factorFactor ix complex for the other "issues" because often we are just trying to self medicate in a destructive manner. As for Seroqual and Librium, I have no experience with those, my apologies. Stay strong!!