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You should talk to your doctor first for additional advice on how to ween yourself off of the effexor. Skipping an entire day or dose in generally not reccomended. I usually advise my clients to start gradually decreasing the dose (under supervision of doctor)...that way the withdraw symptoms are not so severe. Your doctor should be able to help you out with this and advise you exactly what dosages you should take and how much your should decrease your daily dose first.