Need Help!!

I have been having edema episodes for almost 2 years now. At first the dr thougth is was Cellulitis. That has been ruled out now by all kinds of blood tests and skin biopsys.  All has been Negative. All they are findin is the edema.
They are clueless as to what i have. I get these swellings every month like clockwork. Since Feb. of this year its been coming  every month before then it was every other month.  The past 2 months Its gotten to affect my face along with my neck.  This month I had blisters around my lips, cheeks, nose, and forehead. ( herpes zoster has been ruled out ).
They hurt and keep me from working as well. My left eys swoll to the size of a golf ball and in my neck it felt like i had a tennis ball sittin in it right under my chin. Dr said it was water and would slowly go down but this is taking a tol on me and my family.