For the past two nights when I lie in bed, I feel itchy or possibly light pins and needles on my wrists, top of hands, neck, ears, ankles, tongue and left side of face. Two days ago I noticed one of my toenails just fell off although I don't remember bumping my toe. I am a 44 year old woman and in excellent health. (I wrote you last year though that nine years ago I was diagnosed with type 1 herpes in the genital area that has not resurfaced since then but doubt this is related to that). I do not feel any itch in my genital region nor on the trunk of my body, just basically on my extremities. I doubt it is a rash because I itch it but see no hives except one or two small red flat bumps on the outside of my wrists that most probably got there by my scratching. Basically I feel a pins and needles sensation that is not relieved by scratching. I recently started using an intensive lifting cream on my face from Estee Lauder. I also have one pinkish flat ringlike irritation on my leg which looks similar to a ring I had last year that my dermatologist told me was exema (sorry wrong spelling). I am not taking any medications. I stopped smoking a pack a week last month. I suspect I am perimenopausal but am not sure. I plan to see a doctor this week but would be relieved to hear this might not be serious or neurological. Thanks.