My daughter has severe contact dermatitis (Two biopsies with elevated eosinphils; no elevations in Ige general nor specific). Obviously, we can't figure out what is causing it and she has been through nine months of various immunosuppressants, hospitalized twice and several months of steroid treatments. Rituximab has been shown useful in Atopic dermatitis, that is Ige mediated. I understand everything is experimental at this point as we have gone through the whole gamut of typical treatments. I don't understand how this could help her as the biopathology is different. Isn't it? Secondly, there seems to be dissension about contact dermatitis, as some feel that you can only break out where you come in contact with the culprit; whereas, my daughter gets covered from head to toe. Any clarification on this would be greatly appreciated.
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