Starting accutane

Hi Dr. Rockoff,

One more question about starting Accutane.

I think I have read before that you don't usually see a flare up at the beginning of Accutane - but I wasn't able to find that post in my searching....

. I'm going to be starting 20 mg Wednesday and I have a few critical work engagements in the next week.

1. Are the odds good that I won't see a flare up?
2. Is there anything one can do to mitigate one?

Thank you!

[Alan Rockoff, MD]

Despite some references in the literature that suggest the likelihood of early flare, my own experience of 20+ years suggests that worsening at the start of treatment is very uncommon.  I wouldn't worry.  Besides, oral prednisone can always be used for a few days to mitigate a flare even if it happens.

Take care.

Dr. Rockoff