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Dermatology  (Expert Forum)
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Use of alternative drugs causing a recurrance of Erythema Multiforme
Answered by
Alan Rockoff, MD - dermatology, Child Skin Problems
The Rockoff Dermatology Center Brookline - MA
Welcome to the DERMATOLOGY FORUM! Questions in this forum are answered by Dermatologists from St. Luke's Roosevelt Hospital, under the direction of Andrew Alexis, M.D., M.P.H.

Use of alternative drugs causing a recurrance of Erythema Multiforme

by RPS50, Jun 08, 2004 12:00AM
I am a 54 yr. old male with a history of Asthma,sarcoidosis, high cholesterol & borderline high blood pressure. I had been on Zocor,Advair inhaler & baby aspirin for a number of years without any problems. Approximately three or four years ago I started to take Viagra. I not sure how long I was using the Viagra in conjunction with the Zocor & Advair but it didn't seem like a short time. At one point after a weekend of use following manufacturer's directions I developed a severe rash on my torso that spread to my extremeities. I had stopped the Viagra but keep using the Zocor for a few more days. My dermatologist diagnosed the rash as erythema multiforme. It never spread to my oral cavity but it was like I had a chemical burn on my hands,feet & torso.It took a long time to clear up even with the use of steroids, antihistasmines & topical ointments.My internist & immunologist couldn't agree on cause. I had tests for Lupus but they were negative. The internist felt it was the Zocor. I have not used either in the ensuing time period, only the Advair & aspirin.
My questions are: 1) Whether I could try one of the other Statin drugs for cholesterol? 2) Could I try either Levitra or Cialis instead of the Viagra?(could be the more important of the two questions) 3) Do I stand a chance of a worse or fatal recurrance if I try either drug? 4) If you feel I could try one of the alternatives, how to you suggest I proceed & 5) what drugs if any should I have available at home to immediately counteract a recurrance of the Erythema Multiforme?

by Alan Rockoff, MD, Jun 08, 2004 12:00AM
Zocor is more likely than Viagra to have been the cause.  I think it would be risky to try any of the other statins.  Your post doesn't make clear how long you were on either drug before you got the rash--generally, it takes about 3 weeks for a new drug to cause one.  If I were you, I would rely on the advice of the doctors who have seen and taken care of you on this point.

Best.

Dr. Rockoff
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