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I can find plenty of information that warns against long term or widespread use of potent topical steroids, but I have yet to find any actual definition of long term or widespread use. I have several 15g tubes of DesoximetasoneDesoximetasone Desoximetasone topical 0.25% Cream, but I am worried about possible absorption and systemicSystemic lupus erythematosus Systemic lupus erythematosus rash on the face side effects since I saw that it is classified as a Class 2 or Potent topical steroid. The reason I was prescribed the cream is that I have a rash/infection covering most of the area of the front of both thighs. General Practitioner prescribed a course of antibiotics for 10 days and 60mg of prednisonePrednisone Prednisone anhydrous for 5 days(20mg pill every 8 hours), ending last week. Since the rash and/or infection is still not cleared, I saw a dermatologist and I have been prescribed a new course of antibiotics and the DesoximetasoneDesoximetasone Desoximetasone topical cream, which I am supposed to apply twiceTwice-a-day a day for two weeks. Is that enough skin area and/or length of treatment to worry about any possibility of systemicSystemic lupus erythematosus Systemic lupus erythematosus rash on the face side effects, considering the fact that I just got off of a burst of prednisone? Thanks.