big blisters

hi i am looking for abit of help i have skin lesions the drs thought it was pyoderma gangernosum but after been treated for 7 yrs for it they have now said it isnt and have no clue on what it is the call it a mystery skin disease  which they can not treat and i just have to live with it they are real sore and i need to be on morphine for pain after the blister goes the tissue dies and goes gangrene

[maatson]

Are you a diabetic? Acral bulluous diabeticorum is my clinical impression .As  a differential diagnosis I would consider porphyria. Best wishes.

[maatson]

Bullous it is. Spelling corrected!

[cuddle22]

i am diabetic maatson drs havent suggested that have had lesions for 8 yrs over those yrs had about 60 of the lesions will ask him tomorrow ty

[maatson]

Sure, and I feel this is the diagnosis.

[cuddle22]

just read up on internet about it but i suffffer extreme pain uncontrolable at times my lesions last up to 2 to 3 months i will ask dr

[maatson]

Although bullous disease of diabetes lesions often heal without significant scarring, they may be recurrent and also may lead to ulceration.[5] There have also been reports of osteomyelitis arising at a site of bullous disease of diabetes[6]


Tunuguntla A, Patel KN, Peiris AN, Zakaria WN. Bullosis diabeticorum associated with osteomyelitis. Tenn Med. Nov 2004;97(11):503-4. [Medline].

[cuddle22]

ty maatson will look in to those

[maatson]

Had a look at the new photos. A urine test for porphyrins is indicated.

[maatson]

The higher prevalence of diabetes among those with porphyria than the general
population is well-known and well documented.

[maatson]

And also certain anti-diabetic drugs may induce porphria cutanea tarda. Do consult your doc. Best wishes for speedy and complete recovery.