My Mother has had a skin issue going on for almost 2 years. She started with a rash on her hands and face, was given a high dose of erythromycin and became much worse after being out in the sun. She was taken off the antibiotics after going to Urgent Care and since then has visited her pcp, dermatologists, dermatopathologists (2) who took biopsies, rheumatologists, an endocrinologist and no one appears to know what is going on with her. She tests positive for Lupus on first blood test, then after a workup from rheumatologist it comes out negative. She has been given prednisone and cortisone shots but they don't last long. She suffers much and must take benadryl due to the itching. It has affected her quality of life as she can hardly leave the house. Diagnoses have been eczema, dermatitis, but no one doctor seems to know how to treat her. She was given doxycycline and landed up in the hospital for 5 days because it caused her severe constipation and the inability to urinate. No one seems able to help her...any suggestions. Any topical ointments prescribed just burn her...hoping you have suggestions for us.