Can more insulin cause fats deposition?

[Kumar3]

In view of following indicated action of insulin, Can added insulin by medicines or injected cause increase in fats depositions and greater visceral adiposity?



"Increased fatty acid synthesis – insulin forces fat cells to take in blood lipids which are converted to triglycerides; lack of insulin causes the reverse.



Increased esterification of fatty acids – forces adipose tissue to make fats (ie, triglycerides) from fatty acid esters; lack of insulin causes the reverse...



Decreased lipolysis – forces reduction in conversion of fat cell lipid stores into blood fatty acids; lack of insulin causes the reverse.

http://en.wikipedia.org/wiki/Insulin "

[JDRF-Team-RL]

Wow, that is a very technical question.  I'm just a parent, not a medical professional, but I'll take a stab at it.  (Sorry, bad needle pun).  Most of us will only know what insulin does with muscle tissue, not fat tissue.  I've found studies that talk about how high triglycerides can cuase insulin resistance, but not that insulin helps create them.  I've seen studies that talk about how high insulin levels and high blood glucose levels can cause fat storage (ie:  type 2 related).  



So basically I don't know that it's wrong, but I also can't verify that it is correct.  Sorry, not much help.

[Kumar3]

Thanks. Many aspects are still unclear. Probably, insulin resistance starts after fats are stored upto certain level. There may be initial resistance to glucose intake followed by resistance to fats storage.



However, by looking at indicated actions of insulin, it looks that insulin is doing something for fats storage or resisting fat's breakdown?

[JDRF-Team-RL]

I would agree about certain levels of fat storage causing insulin resistance, that's a cause of Type 2 diabetes.  



I just don't know enough about the medical specifics of insulin to answer your second question, although I would caution you to not put 100% trust in anything on Wikipedia.  It's a user-edited site, and anyone can post anything.