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I agree with the previous postings that stress can cause lows, and of course being a newlywed is a stress, even though a GOOD stress. (Good stresses such as happy weddings can cause me to drop unexpectedly low, so it doesn't have to be bad stress that causes drops in glucose.) He and his new wife may want to start setting their alarm clock for about 4 hours after bedtime just to check glucose levels. They can then go back to sleep without worry, and if his sugars are dropping, he can catch them before the numbers are critically low. This little break in the night's sleep is better than risking health. They may want to do this for just a few weeks until his numbers stabilize for a period of time.