My wife, aged 48, has been a diabetic since 1999. She has all along been having some degree of control over the blood glucose levels. Since 2005, she has been taking Duotrol 1/2-0-1/2,& Pioglit15 1-0-0 . But the doctor, seeing her wieght (68kgs) asked her to discontinue Pioglit. Now, since last Sunday(21st of September), we have noticed that the Blood glucose levels have gone past 200.(250,231,222 are the last 3 readings for her Fasting levels,281,274 and 250 the reading for Postprandial) . She has so much tension in her workplace and she is very very tired and exhausted by the time she leaves her work that she cant even stand up.We are very much worried. What should we do? Should we try taking Piogliit again? She follows a strict diet regime, has a good excercise regime also.She also takes supplements like Dprotin. Pls guide us.