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My husband  has been taking prozac for a few years and recently has been diagnosed with acid reflux. Can prozac cause acid reflux? I took prozac for many months with no problems but when I tried it at a later date it really bothered me-- So I am wondering if the prozac may be related.... Please let me know if you think there could be a connection. Thank You
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Prozac can cause some dyspepsia (i.e. upper GI discomfort - occurs in 6 to 10 percent of cases), but I am not aware of a direct connection with acid reflux specifically.  If you note an association with starting Prozac and your GI symptoms, you may want to discuss stopping or modifying your regimen with your personal physician.

For further evaluation, you may want to consider an upper GI series, or upper endoscopy - both studies can evaluate the upper digestive tract for inflammation, ulcers or reflux.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
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Frequent - Prozac (Fluoxetine) Side Effects
Allergic or Toxic: Rash, Pruritus (skin inflammation).
Neurological: Headache, Tremor, Dizziness, Asthenia.
Behavioral: Insomnia, Anxiety, Nervousness, Agitation, Abnormal dreams, Drowsiness and fatigue.
Autonomic: Excessive sweating
Gastrointestinal: Nausea, Disturbances of appetite, Diarrhea.
Respiratory: Bronchitis, Rhinitis (inflammation of the nasal mucous membranes), Yawn.
Endocrine: Weight loss.
Musculoskeletal: Muscle pain, Back pain, Joint pain.
Urogenital: Painful menstruation, Sexual dysfunction, Urinary tract infection, Frequent micturition.
Miscellaneous: Chills
Infrequent - Prozac (Fluoxetine) Side Effects
Infrequent Prozac side effects occurred in at least 1 in 1000 people.

Allergic or Toxic: Chills and fever, Urticaria, Maculopapular rash.
Neurological: Abnormal gait, Ataxia, Akathisia, Buccoglossal syndrome, Hyperkinesia, Hypertonia, incoordination, Neck rigity, extrapyramidal syndrome, Convulsions, Photophobia, Myoclonus, Vertigo, Migraine, Tinnitus, Hypesthesia, Neuralgia, Neuropathy, Acute brain syndrome.
Behavioral: Confusion, Delusions, Hallucinations, manic reaction, Paranoid reaction, Psychosis, Depersonalization, Apathy, Emotional Lability, Euphoria, Hostility, Amnesia, Increased libido.
Autonomic: Dry mouth, Constipation, Urinary retention, Vision disturbance, Diplopia, Mydriasis, Hot flushes.
Cardiovascular: Chest pain, Hypertension, Syncope, Hypotension, Angina pectoris, Arrhythmia, Tachycardia. Gastrointestinal: Vomiting, Stomatitis, Dysphagia, Eructation, Esophagitis, Gastritis, Gingivitis, Glossitis, Melena, Thirst, Abnormal liver function test.
Respiratory: Asthma, Dyspnea, Hyperventilation, Pneumonia, Hiccups, Epistaxis.
Endocrine: Generalized edema, Peripheral edema, Face edema, Tongue edema, Hypoglycemia, Hyperprolactinemia, Weight gain. Hematoligic: Anemia, Lymphadenopathy, Hemorrhage. Dermatologic: Acne, Alopecia, Dry skin, Herpes simplex,
Musculoskeletal: Arthritis, Bone pain, Bursitis, Tenosynovitis, Twitching.
Urogenital: Abnormal ejactulation, Impotance, Menopause, Amenorrhea, Menorrhagia, Ovarian disorder, Vaginitis, Leukorrhea, Fibrocystic breast, Breast pain, Cystitus, Dysuria, Urinary urgency, Urinary incontinence.
Miscellaneous: Amblyopia, Conjunctivitis, Cyst, Ear pain, Eye pain, Jaw pain, Neck pain, Pelvic pain, Hangover effect and Malaise.
Rare - Prozac (Fluoxetine) Side Effects
Rare Prozac side effects occurred in less than 1 in 1000 people.

Allergic or Toxic: Allergic reaction, Erythema multiforme, Vesiculobullous, Rash, Serum sickness, Contact dermatitis, Erthema nodosum, Purpuric rash, Leukocytoclastic vasculitis, Leukopenia, Thrombocythemia, Arthralgia, Angioedema, Bronchospasm, Lung fibrosis, Allergic alveolitis, Larynx edema and Respiratory distress.
Neurological: Dysarthria, Dystonia, torticollis, Decreased reflexes, Nystagmus, Paralysis, Paresthesia, Carpal tunnel syndrome, Stupor, Coma, Abnormal EEG, Chronic brain syndrome, Dyskinesia and movement disorders (including worsening of preexisting conditions or appearance in patients with risk factors {e.g., Parkinson's disease, treatment with neuroleptics or other drugs known to be associated with movement disorders})
Behavioral: Antisocial reaction, Hysteria, Suicidal ideation and violent behaviors. Cardiovascular: Bradycardia, Ventricular arrhythmia, First degree A V block, Bundle branch block, Myocardial infarct, Cerebral ischemia, Cerebral vascular accident, Thrombophlebitis.
Gastrointestinal: Bloody diarrhea, Hematemesis, Gastrointestinal hemorrhage, Duodenal ulcer, Stomach ulcer, Mouth ulceration, Hyperchlorhydria, Colitis, Enteritis, Cholecystitis, Hepatitis, Hepatomegaly, Liver tenderness, Jaundice, Increased salivation, Salivary gland enlargement, Tongue discoloration, Fecal incontinence, Pancreatitis. Respiratory: Apnea, Lung edmea Hypoxia, Pleural effusion, Hemoptysis.
Endocrine: Dehydration, Gout, Goitre, Hyperthyrodism, Hypercholesteremia, Hyperglycemia, Hypothyroidism, Weight gain.
Hematologic: Bleeding time increased, Leukocytosis, Lymphocytosis, Thrombocytopenia, Thrombocytopenic purpura, Thrombocythemia, Retinal hemorrhage, Petechia, Purpura, Sedimentation rate increased, Aplastic anemia, Pancytopenia, Immune-related hemolytic anemia.
Dermatologic: Eczema, Psoriasis, Seborrhea, Skin hypertrophy, Skin discoloration, Herpes zoster, Fungal dermatitis, Hirsutism, Ecchymoses. Musculoskeletal: Bone necrosis, Osteoporosis, Pathological fracture, Chrondrodystrophy, Myositis, Rheumatoid arthritis, Muscle hemorrhage.
Urogenital: Breast enlargement, Galactorrhea, Abortion, Dyspareunia, Uterine spasm, Vaginal hemorrhage, Metrorrhagia, Hematuria, Albuminuria, Polyuria, Pyuria, Epididymitis, Orchitis, Pyelonephritis, Salpingitis, Urethritis, Kidney calculus, Urethral pain, Urolithiasis. Miscellaneous: Abdomen enlarged, Blepharitis, Cataract, Corneal lesion, Glaucoma, Iritis, Ptosis, Strabismus, Deafness, Taste loss, moniliasis, Hydrocephalus, LE syndrome.


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