I am 29 year old woman. Ever since I can remember I have had a "sensitive" stomach. For years I thought it was just stress as well as most of my doctors. I was put on prilosec as a teenager and back then it was prescribed...not OTC. I would have issues off and on throughout my life. I've never been able to drink much because my stomach doesn't tolerate it. I don't take aspirin or any NSAIDS as they too have upset my stomach and make me sick. My symptoms have gotten drastically worse in the last two years. Originally my Doctor and I thought it was just stress because I lost my husband to suicide and months later I lost my son to cancer but my symptoms were persistent. I started having diarrhea badly and vomiting almost daily. I had a scope done and it showed severe gastritis with a small ulcer. I was put on nexium results for H. Pylori were negative. Symptoms improved but only for a couple of weeks. Once again I am vomiting and no appetite. I have lost over 30lbs without trying. 6 months after the first scope I just had another one done. This showed that in less then 6 months I now have 6 large ulcers, but none in the duodenum. Biopsies were negative once again for H. pylori and celiac disease. Doctor has me do a fasting gastrin test. It came back elevated at 1045. My doctor then told me about ZES. They want me to re-do the gastrin test after being off of nexium because I had started taking it 5 days before my test. My question is can taking nexium for 5 days elevate your gastrin levels that much that fast? Also if not ZES what is another likely cause?? I am in treatment but can never get answers fast enough!!! Please help.
My first word is a word of appreciation for the courage you have shown at a tender age
While Nexium can cause an elevation of gastrin levels, it is unlikely that it elevated the gastrin level to such an extent. Zollinger Ellison syndrome would be the most likely cause in your case.
I would also like to bring to your attention some details about Zollinger Ellison syndrome. This is a condition in which there is increased production of gastrin. Usually, a small tumor (gastrinoma) in the pancreas or small intestine produces high levels of gastrin in the blood.
Though a good number of symptoms and signs that you have relate to ZES, it is definitely better to get a second gastrin level done.
The following investigations may help rule out ZES:
• Blood level of gastrin
• Abdominal CT scan
• Endoscopic ultrasound
Your doctor wants you to be off Nexium because it is a part of treatment of ZES, so if you are on ZES there can be false interpretation of the results
If the second level of gastrin also turns high, go for the investigations I have suggested in a phase wise manner and get back to me
Hope that this information helps and hope that you will get better soon.
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