Patient is 30y male with family history of autoimmune thyroid disease
and NIDDM. Symptoms include severe fatigue, hyperpigmentation, minor
alopecia, loss of appetite, bilateral peripheral neuropathies, muscle
weakness and joint pain, and cognitive dysfunction.
Thyroid and adrenal function tests show no abnormalities. B12 normal.
Alkaline phosphatase, AST, ALT, and WBC are low to borderline low.
AST/ALT ratio of 0.7.
Transferrin and Fe normal. Ferritin at 19 (nl range of 30-233).
Hematology panel shows no abnormalities other than borderline
low WBC. Plasma Zn at 52 (nl 75-291), and may explain low AlkP,
a Zn dependent metalloenzyme.
Diet is well balanced and includes red meat. Suggestions?
Possible malabsorption problem? Does not look like Celiac/Sprue.
Zn and Fe appear to compete for same transporter in gut. Are
there hereditary abnormalities associated with Zn/Fe transporter
other than acrodermatitis enteropathica?
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.