Digestive Disorders / Gastroenterology Expert Forum
increase of SGPT, SGOT and GGT value
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increase of SGPT, SGOT and GGT value

I'm 29years male,married no children yet,heavy weight 220lbs,non smoker,non alcoholic,play sport basket ball+golf,I have noticed about 18months ago,my pathology blood test show an increase of SGPT,SGOT and GGT enzyme level and the local doctor diagnosed a fatty liver and treated with HB-pro and Urdafalk and Lipitor/Provacol if my cholesterol is high. I went to consult many doctors and none of them know the diagnose nor give me a right treatment which make me frustrated. The level of SGOT is 50% higher than normal value and the SGPT up to 100% and the GGT is 10~20%. Please advice what caused it and what test should I take to determine the exact diagnose? Can we know by an x-ray or USG what caused it or the only way is to do the liver biopsy? Is it recommended to do the liver biopsy or any medication or vitamin should I consume before I decide to have a biopsy? How dangerous is the risk of liver biopsy? Please advice which doctor or clinic should I consult in Seattle or Los Angeles or other state in US. Just for the additional information, my parent and sister have a normal SGPT, SGOT and GGT level. Thank you and Regards JOE
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X-rays and ultrasound can only suggest disease.  If the liver enzymes remain elevated, then the liver biopsy would be the most definitive test.  Typically, a liver biopsy is recommended if the enzymes are 2-3 times the upper limit of normal.  If you are drinking alcohol, I would abstain and repeat the test within 1-2 months.  

Risks of a liver biopsy include infection and bleeding - this should be discussed with your gastroenterologist before proceeding.  Any gastroenterologist would be able to consider this procedure.  You can contact the American Gastroenterological Association (http://www.gastro.org/) for a GI doctor near you.

I would discuss these options with your personal physician.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
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