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High ALT Liver Test -
I need advice.

I have a year and a half yellow lab.   Last year, when we had his bloodwork done, we noticed that his liver ALT levels were high.  (close to 500)   The vet at that time put him on clayamox for a few weeks and re-tested.  His levels only decreased slighty.   Out of concern, we had a ultrasound done.  Ultrasound results came back absoutley normal.   The vet pretty much said, lets play the "wait and see game"  

Since then, we have switched vets.   We recently had bloodwork done and again my dog's ALT liver levels are still high. (Everything else is normal in his bloodwork!)  My dog acts fine. He's very active, not lethargic at all, eats & drinks well, hasn't been throwing up, no jaundice or anything like that.   The vet now recommended to do a liver bx .   She says, the wait and see game could only lead to more serious things.  If we wait, years to come, if something came up, it may be too late to correct the probelm.  

I've done some research.   Most liver diseases the dog shows signs and symptoms.   I would think
if things were really serious with my dog, he'd be pretty sick. What do you think?

I am doing a liver bx in a few weeks.  

Any ideas on what this may be?  
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My dog, a Sheltie, had a liver biopsy that came back with following result:  cirrhosis of the liver.  He had no symptoms.  The only reason we were alerted to the fact that something was amiss was because of the results of his semi-annual ALT test.  After receiving a bleak outlook for my dog and a recommendation that he be placed on steroids, I did some research on the internet and found an ebook written by Cyndi Smasal entitled Hope for Healing Liver Disease in Your Dog.  Rather than go the steroid route, I followed Cyndi's plan and, after just a few months, my dog's levels were back to normal.  I highly recommend Cyndi's ebook.  Apparently, by the time a dog with liver cirrhosis shows symptoms, it is late in the game, meaning that the disease has already overtaken 75% or more of his liver.   The best course of action is to change the diet and add supplements BEFORE the symptoms appear.  The damaged part of the liver with cirrhosis can't be reversed, but a change of diet along with supplements can help prevent further damage.  Preventing further damage is the key.
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My dog, a Sheltie, had a liver biopsy that came back with following result:  cirrhosis of the liver.  He had no symptoms.  The only reason we were alerted to the fact that something was amiss was because of the results of his semi-annual ALT test.  After receiving a bleak outlook for my dog and a recommendation that he be placed on steroids, I did some research on the internet and found an ebook written by Cyndi Smasal entitled Hope for Healing Liver Disease in Your Dog.  Rather than go the steroid route, I followed Cyndi's plan and, after just a few months, my dog's levels were back to normal.  I highly recommend Cyndi's ebook.  Apparently, by the time a dog with liver cirrhosis shows symptoms, it is late in the game, meaning that the disease has already overtaken 75% or more of his liver.   The best course of action is to change the diet and add supplements BEFORE the symptoms appear.  The damaged part of the liver with cirrhosis can't be reversed, but a change of diet along with supplements can help prevent further damage.  Preventing further damage is the key.
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I have read all the comments about liver disease and I have been working with our vet for two years. Our vet has been very good about both natural and medication.
All her levels except the ALT have gone back to normal. Our vet wants to eventually get her off the medication and just keep her on the natural supplements.
Our dog is not a treat dog, she considers carrots (raw) the biggest treat in the world, but we are looking for other foods that we can give her both in dog food and in what we can make ourselves. But when I look online or ask which are the best I get conflicting answers.
Her ALT levels were not as high as the ones posted and she has never showed any signs or symptoms so we you like to know food wise what we can add or remove from her diet.
Thanks.
A.
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462827 tn?1333172552
Hi Amanda.....How old is your dog & what are you FEEDING now? What has she eaten in the past? What supplements has she been on? Any medication from the Vet?
We need more information....Thanks, Karla
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I took my 9 year old Rat Terrier in for a routine check up about 5 weeks ago, and his ALT levels were at 300. The vet said to come back and recheck in 10 days, because they had sprayed pesticide on our grass that day, and he thought that might have caused it. When we returned, his ALT had jumped to over 500. He suggested changing his food and monitoring him to make sure he wasn't getting into anything (which he wasn't). On the next visit it had jumped to over 900 with still no idea what was going on from the vet, and all he offered was some milk thistle. Meanwhile, I am freaking out, researching possible causes and going into near panic mode while they are beating around the bush, playing guessing games. I understand it is a tough diagnosis, but being really unhappy with the lacking sense of urgency while my dog's life hangs in the balance (among other reasons), I went to a new vet.

On his last visit, it had gone down to 800, after 10 days on the milk thistle with adenosyl (which I found online for $20.99 after paying $64 plus tax at the first vet) so this is still very alarming. We are doing a biopsy Thursday, and I'm near the point of an emotional breakdown, mainly because he is the pickiest eater on earth, even turns his nose up at high quality meat much of the time, and I cannot get him to eat the liver diet dog food, or even the home made version that my vet had me cook. Now he will barely eat anything at all. I think the milk thistle pills - which have added ingredients - upset his stomach. He doesn't show any signs of being sick other than an apparent stomach ache whenever I give him that pill, he is happy and running around the place, except that he won't eat anything other than the liver wurst that we now hide his pills in. He won't even eat cheese - his former favorite thing!!

We did an ultrasound weeks ago, and they didn't find any cancer or tumor, they just said that his liver was very small and inflamed, and that his kidneys were also inflamed. They are stumped. The original vet wants to do a test where they inject dye into the liver and look for a shunt. If they found one, from what I understand, the chances of fixing it are not very good, so that seems like kind of a last resort option. Biopsy first. We've already spent over $800 and the biopsy is going to be around $600. I am a full time student, so between the cost and the fact that I can't focus in school because I'm worried sick over my baby, this is absolutely killing me. They can't figure out what's wrong, I can't get him to eat anything that's good for him, and all the while his poor little organs have been inflamed for well over a month!  He used to eat chicken jerky snacks like crazy, but he hasn't had any in like 5 months, and he used to eat Science Diet, back when he was eating his dog food. Other than that, the only thing that has changed is that we switched him from Heartguard to Trifexis about 7 months ago. I read some horror stories about Trifexis recently (I don't know what to believe anymore -I feel like nothing is safe to give him)!  He won't touch any natural brands of dog food I've tried to give him, like Blue Buffalo.

Can anyone offer any advice / suggestions?? Anything is appreciated, thank you!!  
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462827 tn?1333172552
Hello  Brkawy...
Everything you have listed can cause Liver Damage &/or Kidney Damage! The Chicken Jerky Treats have been poisoning dogs for a few years now! This is well known & been publicized many many times with alerts, cautions, complaints, etc.!
Science Diet is an extremely low quality food & without proper nutrition, no animal's organs can function correctly.....

Your lawn chemicals can do serious damage because they are absorbed through the feet, so make sure you rinse his feet on a regular basis.....

IMO, Trifexis is extremely dangerous because it's a combination product! Too Strong & not worth the risk! There are alarming #'s of complaints about Liver failure & this product...There is actually a whole Facebook page called: "Trifexis Kills Dogs" if you want more information from other owners....

Let me know what you think........Karla
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Hey,
My dog is almost 9 years.
We are on the food the vet recommended which is good for her teeth and her liver. She has been on it for 3 years.
The meds she is on are the ones that the vet has chosen one is all natural which supports the liver and the other is to help repair the damage already done.
With these two meds all her liver counts with the exception of the ALT have returned to normal. Her ALT is noted at 225 as of last week. That is down from previous counts.
We have taken her off any food with preservatives and that is processed. As many people have told us both online, the vets and other people that we have met with dogs with liver problems.
Because everything we have learned and found we know that there are some raw veggies and cheeses that are good for her we are now making some of her meals and mixing it in a bit with her dry food at dinner time in hopes that it will help.
Our vet is really good in the fact that when she found the liver problem she changed every type of medication that she gets and even looked into the needles to make sure that they wouldn't affect the liver.
She also suggest the Benny's Bullies as a possible treat for her (which is a liver one) which she does like but we have check to make sure that is didn't come from China. That is the first thing that we looks at with any food for her.
I just would like to know if there are any foods that we can buy that will help promote liver function that way when she is tested again we can hope for a better result.
Any suggestions would be great.
A.
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Karla - yes, I  saw the Trifexis  Facebook page,  and I  got him right off of it and switched him back to Heartguard,  which he has been on his whole life.  I'm hoping that one is safer...? He hasn't had the chicken jerky in about 5  months -  ever since I went to pick some up and realized they'd been pulled from all the shelves, locally. I  went online and read about it,  and I couldn't believe how long it's been known that they were dangerous,  all while my dogs were still  eating them!  About 5  years!  I'm hoping they haven't caused issues over time,  though it seems like in most cases dogs had pretty immediate reactions to them.  Our vet just put him on special liver diet dog food. I  think it's called  Hill's L/D.  They told me you can only get it through a vet's  office,  and it was $60.  Isn't  Hill's  the company that makes  Science  Diet though??  I'm so frustrated!

@Amanda466 -  what kind of food (brand) has your vet had your dog on for the past 3  years? Maybe I just need to hit up a natural food store and see if they have anything  that specifically promotes healthy liver function.  Unless anyone knows of anything offhand?

Thanks
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Hey,
My dog hs been on the food that your vet has just placed your dog on. We noticed that she like the larger bits compared to the small bites which is good because it promoted her chewing more because her teeth are not the best. As she is a small dog the bag that is the smaller bag lasts her about 3 months as we also for dinner give her veggies and other foods that are good for dogs.
I am just wondering what foods I can give her that will promote the liver function.
I have found that if you want healthy then youend up spending less if you give you dog veggies and chicken that you cook up yourself. Becasue the speciality food sometimes cost more then what you can cook up yourslf.
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462827 tn?1333172552
Brkawy....Here's a link about the LD Canned (Couldn't find the dry).....It may be helpful....Make sure you read the consumer reviews under the article......There will be information you need to read...Here's the link:

http://www.dogfoodadvisor.com/dog-food-reviews/hills-prescription-diet-ld-canned/

Karla
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I recently took my mini schnauzer to the vet because he had been throwing up the last couple of weeks on and off again.  The vet had put him on doggy prozac within the last three weeks.  Once he started throwing up I immediately took him off the prozac hoping that would help his stomach, however it hasn't.  We had a blood panel done on our dog and his ALT was 234 and his ALKP was 54, the vet proceeded to tell us that he was having complete liver failure and that he needed to admitted immediately.  When I explained to the vet that I could not afford the amount of money it cost to admit him, he sent us home with antibiotics and liver supplement with anti-nausea pills.  I tried giving the dog medication he continued to throw it up.  This morning I was able to give the dog a little food and all his medications.  After reading everyone's post my little guy doesn't seem to have as high of levels of everyone else but the vet has scared the crap out of me.  I recently took my dog off of beneful because he was no longer eating it and switched to Natural choice sensitive stomach, is that a good food?  Any suggestions besides milk thistle but it this morning?
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462827 tn?1333172552
How long has he eaten the Beneful? How long has he been eating Natural Choice & how old is this dog? Karla
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He has been eating beneful for 12-14 weeks, natural choice 2 weeks.  My pup is 6 years-old with only 9 teeth, so that is why we put him on beneful it was easy for him to eat, all of the sudden he just stopped eating his food right after he started vomiting.  Thats why I decided to change.
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462827 tn?1333172552
What did he eat before the Beneful? Also, what happened to his teeth at this age? Thanks
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462827 tn?1333172552
Review of Beneful Food: This would make anyone vomit!

http://www.dogfoodadvisor.com/dog-food-reviews/beneful-dog-food-dry/
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He lost the majority of his teeth at 4 years old due to health issues, the vet believes that he was to closely bred.  He has been blue food since he was 4 changed foods due to the fact he would not eat it anymore.
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462827 tn?1333172552
Nutro use to be a decent food, but no longer.....They sold out and changed their formula about a year ago...Many pet parents are having issues w/the new formula....I don't trust this food.....Karla

Here's the link:

http://www.consumeraffairs.com/pets/nutro.html
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Took my Tinker (chihuahua) in for dental cleaning and they did the routine blood work for her procedure.  They called me to let me know about the find, and I have her on Denamarin and Hill Prescription Diet... I wil be going back for her 2nd blood draw in two months.  I only hope what ever she has was caught early.  She is going on two years old.  She is spoiled and we have given her talble food..and probably more treats than she needs...especially peanutbutter...which she loves!.  Her enzine level was 300+ ...3 fold from the normal.  her weight is 8lbs. 8oz.  she is not a bit over weight in looks and shows no sign of any ill sypmtoms.  I'm freaking here... has anyone had this high on liver enzime levels? Patti Jones
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My 4 year old chihuahua has ALT counts of 1600- 2000 for the last two years She has been taking SAMe but we finally decided to get to the bottom of this she had an ultra sound nothing did the liver biopsy and the said she had two bacterial infections going on had her on two antibiotics for 6 weeks went back for blood work ALT is at 1600 now they want to put her on prednisolone and one other saying maybe hepatitis I'm very angry because I thought the biopsy would pin point the problem and now we are back to playing the guessing game very angry
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I am at a loss and freaking out.  My 2 year old male toy poodle named Millie has always been small (4.9 lbs) and his ALT has always been slightly elevated - when he was a pup getting neutered, his ALT was 194.  Vet thinks he might have microvascualr dysplasia.

In early June, my dog started to throw up a bit, and after 2-3 days of an occasional vomit, he vomited all of his breakfast 15 mins after eating.  I brought him to the vet thinking it was a simple stomach upset.  Vet took his blood - Liver levels were through the roof.  His ALT was >2000, his ALP was >2000, his Bilirubin was 5.0.  He was taken to the ICU at a specialty vet and stayed for 4 days.  While at the ICU, they had him on IV fluids, Cerenia (to stop vomiting), Amoxicilin, Metradonzaole (both antibiotics) and they started him on Urisodl, Vitamin E, and Denamarin.  His ALT went down to 1400, ALP went down to 900, and Bilirubim went down to 1.0 at his discharge.  We assumed some sort of toxin caused the problem and kept him on antibiotics for 4 weeks and the other medications indefinitely. We took him to my vet once a week for blood draws.  His ALT went down to 220, ALP went down to 200, and Bilirubin went to .05.   Well, on the 2nd to last day of his antibiotic cycle, my poor baby threw up again.  Scared to death I took him to the vet, and his ALT was <2000 again.  There he had another 3 day stay in the ICU.  They put him back on Cerenia to stop the vomiting and pushed IV fluids.  They continued his medications and his levels went back down.  We keep a tidy home, but before he was discharged I did a thorough cleaning of my house - I vacuumed under end tables, beds, dressers, in every nook and cranny, to make sure he wasn't finding lost pills or something.  My house was spic and span, but I found no toxins.  We bought a muzzle for him to wear outside just in case he had perhaps eaten a poisonous mushroom outside, although we watch him like a hawk and didn't think that was possible.  On July 16, his ALT was down to 520 and his ALP was in the 400's.  On July 26 I took him back in to get his blood levels tested.  His ALT was 930... I don't know what to do.  I'm at a loss.  I just want to help my baby.  He eats boneless skinless boiled chicken breast for breakfast and Euykuneuba puppy chow dry food is out all day.  I've tried to switch him to adult food, but every time I try, he gets an upset stomach.  With his first liver elevations we thought perhaps it was the change of diet (I was trying to change him to adult) but now that it's shot up 3 times, I just don't know what to do.  The vets aren't sure and insist it must be some sort of toxin or bacterial infection.  He gets Dentastix treats but has eaten those for over a year.  I've continued him on the Ursidol, Denamarin, and Vitamin E this entire time.  I just want to help my baby :( Not sure if anyone else has heard of anything similar.
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Hi, I have a 8 year old pomerainian and chow mix. He went for a dental cleaning on Saturday unfortunetly they were not able to clean his teeth because the blood work came back with a ATL of 535. I was told his liver is enlarged and he needs a liver ultra sound. My dog doesn't have any symtoms that's associated with liver disease. I don't know what to do. I also feed him Blue Buffalo dry and the wet in the can. I give him advantage for flee and tic control. And we just started giving hime a heatwormer medicine once a monthe at the advise of his vet. What should I do? I'm scared to death.......
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Did you find out what was wrong with him and is he OK today. I have a dog now with the same problems and readings.

Jerry
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Hi! My dogs levels of ALKP and ALT are high also, and he has been on a natural balance diet of Bison and Sweet Potato! He has been eating this for the past few years since he has many food allergies. Did you find out what was the cause of the high levels in your dogs blood? Any improvements?
He is going for an ultrasound next week, but Im trying to find a holistic approach to this.
Thanks!
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We are currently having this issue.  My 9 year old Maltese had a level of 351.  Discovered when he went in for a dental.  We did the anti-biotic for a bacterial skin infection (tiny little bumps and scaly skin around his mouth and eye) re-tested and it's not changed.  His ALP (or something like that) is 14.9 and normal is 0 to 14.9.  We have started the Denasyl, another anti-biotic (stronger) because the skin issue is not cleared up and this one seems to be working MUCH better.  Plus a couple other things.  My vet is completely on board with trying some natural remedies like the Denasyl (milk thistle).  Al his other blood work is completely normal and no other symptoms of anything being wrong.  I will let you know the results in two weeks!
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My French bull dog had his Alt enzyme level at 1348.  He is 8 months old.  We had xrays, ultrasound and bile acid test.  All came back normal.  He had a tick on him for about a week so vet put him on antibiotic Doxycycline.  He is acting completely normal.  We got him neutered and that is how we found the high ALT.  He is getting blood retest Thursday and we are praying for good results.
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your story is identical to what I was just told by my dog's vet.....my dog is a female lab; 12 years old.  I took her into the vet because if a bad tooth and some scabbing to her lips and a small lump.  Her ALT was 240....everything else looked fine...just wanted to know how your story ended I suppose!  Thank you!
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Wow....so glad I found this site!  I'm worried sick over my 7 year old maltese.  My vet noticed his hair was thinning during his yearly exam.  He had blood work done  and the liver enzymes, along with his bile acids were elevated. They suspected Cushings.   We had an ultrasound on him.  Nothing showed with the liver!  Took him back to the vet after being on denamarin (sp?) for a month.  Liver enzymes are up higher.  The bile acids are also elevated.  Going back on Friday for another bile acid test.  We feed him Little Ceasars.  He's very picky...doesn't even like treats...and that's one food he eats.  I'm now trying Science Diet because someone recommended that.  I just set it down for him...no...he won't eat it!  I'm at my wits end.  He's very active, eats fine, and isn't drinking excessively.  If it weren't for his thinning coat, you'd never know anything was wrong. Any suggestions?  I'm open to all.....
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462827 tn?1333172552
Thinning Hair----Probably nothing more than a nutritional problem......Please KNOW EXACTLY what's in the foods your feeding......You want a food without any chemical preservatives, by-products or dyes....All of these will elevate Liver enzymes.....For further info.:  dogfoodadvisor.com      Karla
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I just went through serious liver Shunt issues with a puppy I rescued. One stop giving  your baby any type of Chemicals at all. His liver cannot process Chemicals. Two stop feeding him any fats and Protein. Three ask the vet about Lactose, Probiotics and pepcid. The Lactose and Probiotics (Denamarin) Helped my baby the best. Also He should be on Hepatic Food there are two. Science Diet and Royale Canine Hepatic formula Dry and Canned. My Baby would go through spells between them and also Home cooked. I did Chicken, Potatoes, Okra, Sweet potatoes Carrots, Broccoli, Very Very little Chicken Lots of Sweet Potatoes, Lots of carrots and broccoli, Some Potatoes and some Oakra. He Loved it. Protein cannot be processed by liver if it is a shunt.
Also I fed my little guy 1 TBS organic ground Beef pancrease as he could not gain weight. This helped him. I also gave him half a childs gummy multivitamin, half a gummy calcium pill. A Dessicated Liver Pill, and a vitamin K tab. 3 CC Ensure twice a day.
I took My Baby to  UC Davis in Sacramento, California,(I am in Arizona) It was $1500.00 for the test to see if he could have surgery to fix his Shunt. However it was not to be. He had multiple shunts so surgery was out of the question.
That is where they added the Lactalose and Probiotics and Pepcip ac to his List of what I was giving him. I had already been told he would probably not live past 3 or 4 Months old. Well the added medications helped. I am here to say he passed away at 16 days before his first Birthday. A Very Sad Day. But the point is that he led a very happy life and the meds I gave and the Vet from the Specialist clinic at UC Davis added Months that he would not have had.

Do Your Research.

Talk to your VET. Ask about these alternatives

Stop Feeding Protein Use low protein  
Keep away from all Chemicals
supplement with vitamins
Do not feed treats unless you make them yourself.
Stay away from all Jerky!

Keep playing with the diet one day he may eat one thing then not the next
I always had various things for him to eat. Peaches are good some cottage cheese some yogurts.
Talk to your VET. Ask about these alternatives.

I pray your Baby's liver issues are minor and that you have Many More Happy Years with Them.
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Our collie has recently had a seizure, he had a blood test and his ALT was extremely high 2950, the vets have never seen this before.  They have suggested that he has a blood test in a months time to see how he goes.   Any ideas  on what we can do,  he is making progress and walking, but his back legs are still abit weak.
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6806351 tn?1384977461
Hello everyone...

I am reading majority on small breeds with liver issues.   I have a 5yo 200lb English Mastiff has just came back with ALT levels of 606.  Prior to this I have been telling the vet he is always sleeping and doesn't want to do anything but sleep!!   She kept saying it was due to his size :(   I am now freaking out and pending results on the bx test done yesterday.  
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6806351 tn?1384977461
I am also new at this issue of high ALT.   I don't understand why your vet didn't want to do additional testing?   Have you thought about a 2nd opinion.   I feel helpless at a level of 606 and I won't let my vet stop testing till I know what I need to do for my Baby!!
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Phenobarbitol can seriously harm the liver in some dogs.
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I lost my beloved heart dog Brody this past Aug. The first symptoms were elevated liver enzymes. I had an ultra sound done and they found a tumor on his liver. I tried to have it removed, but it was inoperable. They called me with him on the table and said he probably wouldn't survive the surgery. They did a biopsy instead. I tried everything to save his life. I also had a special treatment done, called a catheter embolization to try and block the tumors blood supply to hopefully shrink it. I was originally told after the biopsy, that it was a benign hepatoma, but in the end, it spread and had gotten so large that they felt it was definitely malignant. I guess the biopsy was useless. The embolization didn't really help either. I lost my Brody about 8.5 months after diagnosis. I had to let him go. It has been almost 6 months, and I still can't get over the pain and sadness of his loss. He was everything to me. He was only 8 years old. He should have had 8 more. My advice is, if the liver enzymes are at all high, do NOT ignore it. Do additional tests, ultra sound… I had been told about a year before the tumors discovery, that his liver enzymes were "just slightly elevated", and I should have them retested "whenever". The vet didn't make a big deal about it at the time, so I didn't think it was. Usually my vet is all about testing, and a lot of times they are over cautious, so when they didnt make a big deal out of it, I forgot about it. If only I had known what it might have meant. Maybe I could have found out sooner, maybe I could have saved him. He wasn't retested until almost a year later, after he suddenly had diarrhea that wouldn't go away. It came out of no where. I never expected to find out he had a tumor. He seemed so healthy and happy. The only thing that was wrong was the diarrhea, which I had taken him to the vet several times for. They said the two weren't even related…I would have done anything for him, but there was nothing I could do. I had to finally let him go. I have not been the same since. I feel like a light went out in my life.
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ook my 10 year old dog in to have a mass removed from her right side on Jan. 2nd - it turned out to be cancer. When they did the pre-anesthesia screen her ALT was 108...I just had a full blood work panel done yesterday Jan. 22nd - CBC, Thyroid, Chemistry...her ALT is now 216 BUT the vet said that could be from the anesthesia still being worked out of her system, or the medications she took afterwards.

Other than her cholesterol being a bit high, everything else looked good. So is the jump in her ALT levels totally normal..or is something else going on?

Having her tested again next month. Trying not to think the worst...but seeing the lab report on the mass has me freaked out.  

:(
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sorry to hear...i know how sad it is...I've had 6 animals plus a horse put down due to old age (cancer, stroke etc) in the last 6 years. The oldest cat was 16 and the youngest cat was 8. The others were my dogs who had cancer, stroke and just general old age diseases. I put my horse down last week and my last dog who is 14 has kidney issues so its nearing the end again. I sympathize with you...its very difficult when they are your best friend and not that old.  You are not alone though as my neighbour had to euthanize her dog at four as he had some kind of inoperable issue and was suffering. She was very very upset about losing him. It sounds like you did everything possible for him. Even if they caught something early there is no guarantee it would have mattered. My neighbours dog was okay one day and the next week he was gone. Hang in there...you did everything you could.
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7536605 tn?1391734935
I have a French Bulldog I've been going through high ALT issues with. What ended up being the issues with your frenchie? My Frenchie was diagnosed with demodex mange so we treated him with ivermectin at the vet's direction for roughly 8 weeks until it cleared up. He was then pre-neuter given a blood draw and his ALT level was 1121 and all his other levels were normal. We then did a bile acid test to rule out a liver shunt, that test came back normal. He was then put on Denamarin to help his liver after the Ivermectin. 2 weeks later blood was drawn again and his level was 953 so we are continuing the remaining 2 weeks of his Denamarin to redo the blood draw and maybe do an x-ray pending that result. He's not showing any symptoms and appears healthy. Does anyone have any similar stories to share or advice? We're really not sure what's going on. The vet said they could neuter him, but we opted to hold off given the risk.
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Just had to hospitalize my 8yr old boxer/bull mix. He was started on thyroid meds about 3 weeks ago during blood work was told  at was slightly high but probably due to weight and age.  He was given updated rabies/distemper and had to return for booster shot and also recheck of thyroid.  He had booster on Saturday ate food later that day and was fine. Sunday he quit eating, ate some on Monday by hand feeding and got him to eat Wednesday night. Thursday am he threw up twice. Took him to vet and now his atl is 1200.  Hesnhaving xrays and fluids and everything dog hospitalization brings.  In don't understand in 3 weeks time how things changed. He's been acting the same , heck more energetic since thyroid meds.  Now they're cheching for liver disease or possible mass. I don't know what to do or what caused this! Any insights or recommendations??
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DO Not give any chicken jerky or strips!!!!
Most of it is made from tainted chicken from China..especially Milo's kitchen treats!!!!!
They will go
Into renal failure and die.
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9644933 tn?1407772490
I have a 3 year old Australian Shepard who is deaf due to a double merle breeding. I brought her into the vet several times with concerns that she just didn't seem right. Occasional diarrhea, inappetance, frequent drinking and increased urination were all on my list but they were never consistent symptoms as they would come and go. On top of this I had been working with her and a vulva issue for months that included multiple vet visits, creams, etc. They finally said she had urinary incontinence and put her on a steroid. Nothing helped. Finally I took her back in and insisted on blood work. All was normal aside from an ALT of 235. The vet proceeded and gave her 3 vaccines as part of an annual checkup. Lepto, Lyme and Rabies. I was told to retest in 3 weeks to see if the levels would lower. I didn't make it to 3 weeks. Two weeks later she threw up bile and would tremble after the smallest amount of food which I really had to coax her to even eat. I brought her into the vet and just two weeks later ALP of 202, TBIL of 11 and ALT of 1392. I rushed her from my regular vet to a DMV medical center with 24 hour care where she was on IV for 72 hours and an ultrasound was performed. Despite the time on IV her blood levels never dropped. The ultrasound showed no signs of a shunt or tumor but they did advise her liver was very small and abnormal in shape. The specialist said that he felt we were dealing with a chronic liver disease which would result in failure, but the only way to know for sure was a biopsy. When I asked if the biopsy would determine the cause to cure her, he said no. He felt strongly she was born with a defect and managed up till this point. Pre blood work even demonstrated that her clotting factors were down so the biopsy was a risk in itself. I made the decision to bring my baby home as I did not see the point of her spending any more time there. He advised me with her levels and no improvement, I probably had 2 days and he sent me home with a small supply of a nausea meds and a probiotic. At this point I took to the internet and researched and reached out. It's been 6 weeks now that she is home. Maintaining her takes all of my time outside of my employment as I cook for her, feed her many small meals, time her supplements etc. It is of course worth it. I have brought her back twice since initially brining her home for further exams on her vulva. They took a culture and prescribed Baytril to treat a susceptible infection.  Each time I have brought her in since they run urine and blood work. Last week her urine gravity was almost normal as was all her blood work aside from an ALT of 234. Next week I am taking her in for a biopsy of the skin on her vulva and a bile acid test to determine the function of the liver. I am still not comfortable with a liver biopsy at this time. Was it the steroids that caused this, the vaccines, the infection of the vulva, her genetics? The point is I don't know if I will ever really know and that seems to be the frustration with the liver. All I can hope is that my little girl can stay stable and I hope the drop in enzymes is in fact a sign of recovery and not a cover up from the remedies I was been practicing. I currently give her denosyl, a liver cleanse, vitamin K and most importantly I am cooking for her myself. All natural and balanced. Is what I am doing helping, is the baytril playing a big role? Again, I don't know. All I know right now is she still wags her tail when I get home. After I wake her up of course, since she didn't hear me come home... ;)

I guess I am posting this to share my experience, learn from others and offer any advice on what I have done so far if it will help anyone else. Hope to see some action soon. Thank you in advance!
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DONT feed Milos. It's the worst thing you could give him. Look it up on the internet. It's all made in China with no food requirements so you don't know what they are using. I use Nudges Jerkey Cuts. Made in America.by Tyson. Please do an internet check on any food you give your dog. Food you may think is fine actually is toxic.
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How is your dog?  Mine is going thru something similar and I have been researching different foods to feed him homemade.  It's all so confusing.  He has to be on low fat and low protein.  Hope your dog is doing much better.
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9644933 tn?1407772490
She is doing much better now. Thank you for asking. It is confusing because there is SO much information out there. I went into survival mode when I was told we didn't have much time left and researched like CRAZY!
Her specialist formulated a couple of recipies for homemade food. They are simple in ingrediants. I would be happy to share what I have with you. One site that gave me some hope was http://www.scamperingpaws.com/liver-disease-dogs/. I found it to be realistic and close to what I was going through. It may help you as well. What kind of dog do you have? How old?
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I too went thru the dehydrated chicken strips from China . My dog had bleeding colitis and had anti biotic therapy for two days, she is doing well, but now has an elevated enzyme in liver, we are looking at possible cause heart worm pill now? It's scary when you don,t know what is causing it?
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My vet in NC recommended Denamarin for pets - it works a lot like milk thistle - and little Rosie's ALT has come down in the past year from 848,000 last June to 149,000  on  2-6-16 (high normal is listed at 100,000) - I did a lot of research on this and found a lot of books with diets - I found a good book by Cyndi Smasal called Hope for Healing Liver Disease in Your Dog. I hope things worked out well for you as I a lot of time has passed since your post. Hopefully it will also help someone else doing research for their dog.
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I am so sorry about your little dog mine as well has a high liver count and also did a bile count which was high. I understand deliver can rejuvenate itself I can't afford to have a ultrasound so I have to go with my gut and tell myself to do with the doctor said which was Royal canine for liver disease dogs I give my dog you know quarter of a can at a time when she will eat fresh water from a bottle and lactose for her gut an antibiotic she also get say Sam e for dogs with liver problems I hope I am doing enough,she's all I have left.
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I recently had full bloodwork done for all of my dogs. My lab - who has in-remission autoimmune issues - has tested high twice for alb:glob @1.3, and alt @249. I had been giving her MultiGuard Plus for years - which contains Ivermectin. My Q is, I am stopping that now - based on your post (THANK YOU); how long would it take for enzymes to reduce if that is the culprit? Switching to Interceptor as you recommend. OR 2nd Q: how dangerous is it really to not give heartworm prevention to dogs? Because of the autoimmune, she gets mininal vacines - is heartworm medication likely to trigger an eposide? And hell, it seems to me that NONE would be a whole lot healthier than giving them something you can legally buy, but turns out to be POISON. Good GOD. Thank you. -deb
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PS vet has her on Denamarin in the meantime.
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And ultrasound showed nothing
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OMG I have been reading all this I'm learning so much I have a little 5# yorkie Bella she starting vomiting and diarrhea 3 days ago not eating or drinking took her to the vet was told her liver enzymes were elevated ALT was 318 I am devastated going back In a month for re check any thoughts
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Thanks Karla for the valuable information. We have been running pillar to post since a year for our 6 year old lab. We moved to vietnam a year back and he has been having his ALT levels high since then which led to his skin problems and the vets here had no clue why. I think the answer might be Heartgard which the doctor started him on every month since we moved here. This does contain Ivermectin. We shall stop this forever now and see how he fares. Thanks again karla.
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