They are getting Purina puppy chow, Should I try a different kind of food, just in case that is the problem? How long should they be on puppy food? They are both really big the male is 44 pounds and the female is 36 pounds and they are only 4 months old so they are going to be really big , they both get 1/2 a cup of food three times a day ,is this enough or too much? I will probably take them to a vet as well for a check up just to be on the safe side.
I would also recommend you take them to see a vet and bring a stool sample also. When I got my Great Dane puppy he had the runs really bad and I ended up taking him to the vet where she gave me some antibiotics for him and he cleared up well. I found out about 2 months later that all but two of the puppies from that litter died from parvo. He is now 1.5 years old and healhy. I hope they feel better.
Have they been checked for worms? What brand of food are you feeding them?
You really should have them seen by a vet. Puppies can become dehydrated quite fast.