Epstein Barr Virus (EBV) Community
New Drug for EBV
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This patient support community is for discussions relating to Epstein Barr Virus (EBV), chronic EBV, and infectious mononucleosis (mono).

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New Drug for EBV

MARIBAVIR has proved very effective and nontoxic treating Epstein-Barr Infectious Mononucleosis. Medical papers on the subject published on widely circulated medical journals as flws:

1) Journal of Virology - Sept. 2009
Maribavir inhibits Epstein-Barr viral transcription in addition to viral DNA replication
http://jvi.asm.org/cgi/content/abstract/JVI.01575-09v1
Paper published by:
Fu-Zhang Wang, Debasmita Roy, Edward Gershburg, Christopher B. Whitehurst, Dirk P. Dittmer,  and Joseph S. Pagano
Departments of Microbiology and Immunology and Medicine, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC; Dept. of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield IL 62794

2) Journal of Antimicrobial Chemotherapy - July 2005
Epstein–Barr virus infections: prospects for treatment
http://jac.oxfordjournals.org/cgi/reprint/56/2/277
Paper published by:
Edward Gershburg and Joseph S. Pagano
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill,
Chapel Hill, NC 27599, USA

3) ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2004
Effects of Maribavir and Selected Indolocarbazoles on Epstein-Barr
Virus Protein Kinase BGLF4 and on Viral Lytic Replication
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400567/pdf/1030-03.pdf
Paper published by:
Edward Gershburg,1 Ke Hong,1 and Joseph S. Pagano1,2,3
Lineberger Comprehensive Cancer Center,1 Department of Microbiology and Immunology,2 and
Department of Medicine,3 University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina 27599

4) ViroPharma statement ref. actual status of MARIBAVIR development.
http://www.viropharma.com/pipeline.aspx

I have to cope with recurrent relapses of EBV.

Does anybody know whether there is a way to get access to this new drug?
2 Comments Post a Comment
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1070570_tn?1283439813
Hey! I haven't ever heard of this? Is it brand new? I will ask my doctor about it. I am supposed to be starting something called "transfer factor plasmyc" that is supposed to rid me of my EBV in 6 months. It works for some people and not for others, but it's worth a shot. I have had so many relapses of EBV. I am 23 now and I first got it when I was about 16. It's been a long hard life since then. I'm also hypothyroid.

One question, do you happen to get throat infections that resemble strep throat with white spots or patches on your tonsils when you have a relapse?
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Avatar_m_tn
Hi! MARIBAVIR is an experimental oral antiviral drug candidate licensed by ViroPharma from GlaxoSmithKline in 2003 for the prevention and treatment of human cytomegalovirus disease in hematopoietic stem cell/bone marrow transplant patients. It showed promise in Phase II clinical trials and was granted fast track status, but failed to meet study goals in a Phase III trial. (Pls check "MARIBAVIR" on Wikipedia).

However the drug proved to be very effective in treating EBV. The main researches on efficacy of MARIBAVIR to treat EBV have been carried out since 2003 by Prof. Joseph S. Pagano et al. at Chapel Hill University (NC). (Pls check the links provided in my previous post). Moreover pls check Prof. Joseph S. Pagano's medical papers on Google Scholars, he is carrying out in-depth researches on EBV since many years, due to the fact that the virus is considered to be the underlying cause for many kinds of malignancies (lymphomas), Multiple Sclerosis (MS) and aggressive NK-cell leukemia.
Prof. Pagano's site link as flws:
http://www.unclineberger.org/research/faculty/displayMember.asp?ID=137

If you are considering to ask your doctor about MARIBAVIR I kindly advise to show him the medical papers I have referred to in my previous post. MARIBARY is a very new breakthrough (last very important medical paper on the subject is dated Sept.09) so I don't expect many doctors to be already acquainted with the issue.

Recurrent Active EBV (CAEBV) is endemic in Far East (Japan - Korea). CAEBV is a high mortality and morbidity disease with life-threatening complications. Nevertheless, the treatment regimens for CAEBV have not yet been established.
Allogeneic bone marrow transplantation and allogeneic hematopoietic stem cell transplantation have been tried with some success in Japan.
Free PDFmedical papers can be downloaded at the flwngs links:
(1) http://www3.interscience.wiley.com/cgi-bin/fulltext/120174894/PDFSTART
(2) http://www3.interscience.wiley.com/cgi-bin/fulltext/119878250/PDFSTART

Moreover treatment based on infusions of autologous Epstein-Barr virus (EBV)–specific cytotoxic T cells has proved quite effective in the past.
From the Center for Cell and Gene Therapy, the Departments of Pediatrics and
of Medicine, Baylor College of Medicine, Houston, TX; the Departments of
Medical Immunology and Nephrology, Charite´ Hospital, Humboldt-University of
Berlin, Germany; the Department of Pediatrics, National Jewish Medical and
Research Center, Denver, CO; and the Lineberger Comprehensive Cancer
Center, University of North Carolina at Chapel Hill.
Free PDFmedical paper can be downloaded at the flwng link:
http://bloodjournal.hematologylibrary.org/cgi/reprint/100/12/4059

Ref your question about throat infections: my tonsils have been surgically removed when I was 6 years old. Obviously I do get recurrent upper respiratory tract infections, i.e. rhinitis (right side), pharyngitis (right side), laryngitis (right side), uvula megaly, as well as gingival ulcers (both sides), measles like erythema on the genitals, sudden left arm paresthesia, sudden diarrhea followed by 1 to 2 days constipation, sudden episodes of light angina pectoris of short duration. Almost all symptoms showing at relapse on-set.

Last week I wrote a letter to Prof. Pagano ref MARIBAVIR but I didn't receive any reply so far.


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