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The mechanism of action of these drugs suggests that they are metabolized and excreted extensively through liver and extensively plasma and tissue bound.
Hence creatine does not have an effect on these drugs.
You are asking question as to whether high creatine interferes with this drug or are you asking can you take creatine supplement with these drugs.
I assume you are asking the first question which I think I have dealt with.
Keep me informed if you have any queries.
Bye.