I have taken Lumigan for open Angle Glaucoma for a couple of years in one eye only. In April the ophthalmologist asked me to put them in both eyes. I have no problems with that and my IOP is well controlled. However, I noticed my PVC's have gone up considerably since taken the drops. At first with only one eye I had about 15,000 per day, now with drops in both eyes they have gone up to almost 30,000 per day. There where no other medication changes during that time. I don't think that the active ingredients cause the problem, but what about the Benzalkonium Chloride (BAK) that is the preservative in the drops, could that cause the problem? has there been any research done on this?