Can a Pheochrymocytoma not show up on urine, blood and or MIBG scan? Do you have to catch some Pheos in an active state

Can a Pheochrymocytoma not show up on urine, blood and or MIBG scan? Do you have to catch some Pheos in an active state or episode to detect?

[Kevin Pho, MD]

There is no test that is 100% sensitive, meaning there is always a chance that tests can miss the disease.

The sensitivity is best with the blood metanephrines (99 percent) followed by urinary fractionated metanephrines (97 percent).  These tests should be considered if you want to ensure a pheochromocytoma isn't present.

Regarding imaging, this should normally be done after biochemical tests.  The MRI would be the most sensitive, but still not 100 percent.

These options should be discussed with your personal physician.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
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